How to highlight the anti-cancer effect of various plant extracts?

Some active substances extracted from plants have been proved to have good medical effects In fact, extracts from many plants have special anti-cancer potential In recent years, scientists have found that many plant extracts can help fight against cancer For example, in a research paper recently published in the International Journal of natural products, researchers extracted special compounds from the seeds of parsley and dill, which can help to prepare new drugs with anti-cancer activities In this paper, a number of relevance studies have been organized to clarify how plant extracts have magical anti-cancer effects and learn from you! 【1】 Can a broccoli spray pill light cancer? A compound found in broccoli shoots not only helps prevent cancer, but also hopes to cure it This compound, called sulforaphane, is widely found in vegetables, such as cabbage, broccoli, cabbage, and especially in high concentrations of broccoli buds Sulforaphane can also be used as a dietary supplement for the treatment of degenerative neuropathy (BSE) Scientists at the Texas Center for agricultural, industrial and Health Sciences and researchers in Oregon have previously found that sulforaphane can inhibit colon and prostate cancer cells in vitro in laboratory cell tests They have now shown that the compound has a similar effect in humans In a clinical study, 28 volunteers over the age of 50 were undergoing routine colonoscopy The researchers also conducted a survey of their eating habits with cruciferous vegetables Their colon biopsies found that those who ate broccoli regularly had higher levels of p16, a tumor suppressor gene, compared with those who ate little or no cruciferous vegetables 【2】 Nutr cancer.: grape seed extract can effectively kill cancer cells doi: 10.1080/01635581.2013.785003 scientists at the cancer research center of the University of Colorado synthesized the most effective component b2g2 of grape seed extract in the laboratory, which can cause prostate cancer cell apoptosis without harm to healthy cells Relevant reports are published in the recent journal of nutrition and cancer According to alpna Tyagi, Ph.D., a researcher at the cancer center of the University of Colorado, the corresponding author of the article, we have previously found that grape seed extract (GSE) has the anti-cancer effect, but we did not know the effective ingredients of the extract before Dr Tyagi said that although we found the role of b2g2, extracting b2g2 from GSE is a very time-consuming and expensive process Due to the difficulty of b2g2 separation, the scientists revealed that the progress of its function was slow So Dr Tyagi decided to synthesize b2g2 in the laboratory The yield of synthesis method is high and not expensive The scientists further studied the antitumor effect of the synthesized b2g2 It was found that b2g2 had the same antitumor activity as GSE 【3】 ACS: hops extract is expected to treat breast cancer doi: 10.1021/acs.chemrestox.6b00112 in a new study, UIC / NIH Center for botanical dietary supplements, University of Illinois, Chicago Researchers at research have found that enriched hops extract activates a chemical detoxification pathway in breast cells that may help prevent breast cancer The relevant research results were published online on June 7, 2016 in the Journal of chemical research in toxicology, a sub Journal of the American Chemical Society (ACS) The title of the paper is "hop (Humulus lupus L.) extract and 6-prenylnaringenin induct P450 1A1 catalyzed estrogen 2-hydration" Natural plant-based dietary supplements such as hops are becoming more popular among women with postmenopausal symptoms because they are considered a safer alternative to hormone therapy - associated with an increased risk of breast cancer However, the efficacy and potential toxicity of botanical drugs are still under study In the new study, correspondence author Judy Bolton, a professor of pharmaceutical chemistry and pharmacognosy at the University of Illinois, Chicago School of medicine, and her colleagues added hops extract to two different breast cell lines to see if it could affect estrogen metabolism, a key mechanism in breast cancer As a compound in hops extract, 6-pronylnaringenin (6-pn) enhances the detoxification pathway in these breast cells, and the increased activity of this detoxification pathway is associated with a lower risk of breast cancer 【4】 CCR: a new anticancer compound doi: 10.1158/1078-0432 was found in the flower Wang Hui, research group of Shanghai Institute of nutrition, Chinese Academy of Sciences, and Zhang Weidong, the Second Military Medical University of Shanghai worked together to screen and identify the double anti-tumor effect of the extract from the flower of traditional Chinese medicine Japonicone a (Ja), a natural product of semiterpenoid lactones, was found to be a natural NF - κ B inhibitor, which can significantly inhibit the growth and metastasis of lymphoma cells Recently, the academic journal clinical cancer research published relevant research papers online In recent years, the number of new cases of lymphoma in China is increasing, and tends to be younger and urbanized Previous studies have shown that NF - κ B signaling pathway mediates the occurrence and development of lymphoma and other biological processes The abnormal activation of this signaling pathway is one of the main reasons leading to metastasis and chemotherapy resistance of malignant lymphoma Therefore, drug development targeting NF - κ B signaling pathway has become a new strategy for the treatment of this kind of disease 【5】 PLoS One: grape seed extract can reduce the toxicity and enhance the efficacy of chemotherapy for colorectal cancer doi: 10.1371/journal.pone.0085184 recently, a new study from Adelaide University showed for the first time that grape seed can assist chemotherapy in killing colon cancer cells, while reducing the side effects of chemotherapy The study, published in PLoS One, said that chemotherapy combined with grape seed extract has the potential to become a new method for the treatment of colorectal cancer Grape seed extract not only reduces the intestinal damage usually caused by cancer chemotherapy, but also improves its effect Dr Amy Cheah, lead author, said that recently, there has been increasing evidence of the health benefits of grape seed tannins or polyphenols as anti-inflammatory agents and antioxidants, as well as their anticancer properties This is the first time that studies have shown that grape seed can enhance the effect of chemotherapy drugs on colon cancer cells Dr Cheah said, our study also shows that in laboratory studies, grape seed can significantly reduce the intestinal inflammation and tissue damage caused by chemotherapy, but has no harmful effect on non cancer cells 【6】 Compound in Magnolia may combat head and neck cancers magnoliae plants are famous for their colorful flowers In addition, Magnolia and honokiol extracted from magnoliae plants have been used as traditional Chinese medicine for centuries Recently, scientists from the United States published a new research progress in the international academic journal oncotarget They found that magnolol and honokiol have remarkable effects in the fight against head and neck cancer According to data from the National Cancer Institute, at least three-quarters of head and neck cancer patients are caused by the use of tobacco and alcohol This type of cancer has a survival rate of only 50%, and about 20000 Americans die of head and neck cancer every year Honokiol, a major active component of Magnoliaceae plant extracts, has been used in traditional Chinese medicine for centuries to treat anxiety and other diseases Later, it was found that honokiol has a certain role in cancer treatment, which may activate multiple signal pathways in a variety of cancer cells to inhibit the growth of tumor cells 【7】 PNAs: ginseng extract can help alleviate the side effects of cancer therapy doi: 10.1073/pnas.1111332108 US researchers reported on August 15 that animal research shows that the active component of ginseng extract - panaxytriol and similar compounds can help alleviate the side effects of some cancer therapies Researchers at the Sloan Kettering Cancer Institute in New York synthesized a compound similar to panaxytriol, and then tested the compound's ability to counteract the side effects of chemotherapy or radiation in mice with breast or colon cancer The results showed that the compound could reduce the weight loss and blood cell damage caused by radiotherapy The researchers believe that panaxytriol and similar compounds can reduce the weight loss caused by peripheral nerve injury and nausea caused by paclitaxel, and reduce the damage of 5-fluorouracil to red blood cells and white blood cells, thus reducing the risk of infection and anemia in the drug users 【8】 Oral milk thistle extract stops colorectal cancer stem cells from growing tumors At the 2015 annual meeting of the American Association for cancer research (AACR), scholars from the University of Colorado presented the latest research results on the ability of oral silibinin, a new potential drug for colorectal cancer treatment, to slow down the growth of colorectal cancer stem cells After silibinin treatment, the tumor stem cells sampled were reinjected into the new model, and the cells failed to develop the same aggressive tumor, even without silibinin Silybin is a nontoxic and potential chemical preventive agent in milk thistle seeds At last year's AACR annual meeting, Dr Agarwal and his colleagues found that silybin in cell cultures affects cell signaling related to the formation and survival of colorectal cancer stem cells Now, this promising study extends to this mouse model The researchers implanted colorectal cancer stem cells into mice that were fed with or without silybin Tumor growth was measured by visible size measurements, MRI scans, and tumor metabolic rate (glucose use) Tumor stem cells from the mice were then reinjected into the next generation of mice to measure tumor growth patterns without silybin 【9】 The extract of Cimicifuga can inhibit the growth of human cancer cells Cimicifuga is a famous traditional Chinese medicine in China Its functions of clearing away heat and detoxification, Promoting Yang Qi and releasing rash have been recorded in Shennong herbal classic Recently, a series of new compounds have been extracted from Cimicifuga by Kunming Institute of Botany, Chinese Academy of Sciences Their efficacy can inhibit the growth of human cancer cells, and provide a new direction for anti-tumor research In order to make full use of the resources of cohosh, since 2005, the resource phytochemistry research group of Kunming Institute of botany has collected, separated and purified the cohosh, including Yunnan cohosh, Xing'an cohosh and Trifolium cohosh, identified its structure, screened its biological activity and enriched its active compounds More than 60 new compounds of Cimicifuga were isolated, and a series of active components with anti breast cancer activity were found first