How to ensure the quality of solid preparation products? Preparation technology and equipment give answers

Pharmaceutical Network Technical Article: In pharmaceutical products, solid preparations are widely used, more varieties of a dosage form, about 70 to 80%because the starting raw material of solid preparation is powder, in order to ensure the quality of solid preparations and the smooth progress of the production process, it is often necessary to process and process the drug, including crushing, grading, mixing, granulation, drying, pressing tablets, etc, each step of unit operation is permeated with the application of powder technologyindustry pointed out that the preparation technology and pharmaceutical equipment is the smooth operation of powder to ensure the smooth operation of the guarantee, but also to ensure the quality of preparation products an important tool, it is important to select suitable accessories and to use appropriate preparation techniques and equipmentHowensure the quality of solid preparationproducts? Preparation technology and equipment give the answer (source: pharmaceutical network) to the tablet preparation process for example, this is a drug and suitable auxiliary mixture and uniform suppression of the flacular solid preparationthe preparation process of the generalization tablet can be divided into: filling, compressing and pushing the three steps of the materialin order to ensure the quality of tablets, in the prescription design and screening of accessories, it is generally necessary to consider the effect of the powdery properties of tablet materials on tablet molding, including the liquidity of tablet materials, compression molding, quantifiable analysiswith the development of new accessories and high-efficiency tablet equipment, tablet production has entered an era of high efficiency, energy saving and high qualitywhich in the tablet, according to the nature of the powder, generally using granulation tablet method or direct pressure chip method, the grain-making method can be divided into wet legal particle-pressing method and dry legal grain-pressing methodspecific point of view, the wet legal particle pressure method on raw materials or accessories of the powder nature of the requirements are not high, can solve the problem of raw auxiliary powder properties, access to good fluid particles, significantly improve the compression and forming of the drugbut the disadvantage of wet legal particles is not applicable to wet heat unstable drugs, may appear in the process of tablets sticky punch, top cracking and so onmethod of crushing the granulation after pressing the mixture of raw materials into thin flakes or large sliverscan also significantly improve fluidity and compression forming after granulation, mainly for wet and unstable drugs need granulation when the effective methodhowever, this method on the nature of the auxiliary powder is higher, the auxiliary material should have a better plastic deformation, compression forming or has the role of dry adhesive, otherwise the pressure after crushing the grain is easy to crush into powder, the yield of particles is not highin recent years, with the continuous development of modern science and technology, as well as GMP standardization and the promotion of QbD concept, powder treatment methods continue to seep into the preparation process of solid preparationsat the same time, because the formulation technology and pharmaceutical equipment directly affect the quality of the preparation products, so in the current pharmaceutical industry on the preparation products more and more demanding background, upgrade the formulation process technology, improve pharmaceutical equipment has become a trendat present, the domestic high-end solid preparation equipment market is mainly occupied by Germany, Italy and other foreign manufacturers, some manufacturers also plan to establish solid preparations in China process center, for domestic customers including to improve the production process of customers, to help customers to achieve high-volume production of personal services, while providing customers with equipment, technology trainingcompared, domestic solid preparation equipment manufacturers are also mainly concentrated in the low-end market, competitive means to low-cost warfare-based, the number of leading enterprises is not muchwith the promotion of generic drug consistency evaluation, the normalization of volume procurement, the pharmaceutical industry to speed up the upgrading, domestic solid preparation equipment will have a larger growth spacefrom the trend point of view, the industry believes that the continuous production model is currently a lot of solid preparation enterprises to explore and practice the development model, that is, from the raw material into production to the end of the finished product, in accordance with the process requirements, each process is carried out in orderexpect this model to be a development direction that the industry needs to study in the next five years or soin this context, some domestic solid preparation equipment manufacturers in recent years also actively expand the layoutsome enterprises said that in 2020, the company will focus on the "solid preparation intelligent factory overall solution supplier" and the strategic layout of the large health industry, continue to deep-dive pharmaceutical equipment market and intelligent logistics industry, and strive to become an international pharmaceutical equipment intelligent factory line solution suppliers, and continue to promote the large health industry in depthalso have enterprises through the multi-year layout, to promote a vertical and one platform strategy, and constantly enrich the product line, enhance the competitive advantage in the field of solid formulations, to create competitive solid formulations overall solutions and build pharmaceutical wisdom factory