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Pharmaceutical Network Technical Article: In the production of solid preparation tablets, mixing and granulation is the key to determine the quality of tablets or capsules, in a sense, granulation is the key basis In the past, the industry when the use of grain is more wet legal grain equipment, and today's wet legal grain equipment has developed to high-speed mixed granulation machine, which is a relatively fast development in recent years a solid preparation pharmaceutical equipment, mixing, granulation two-step process together, not only save time and meet the GMP requirements, reduce cross-contamination, improve efficiency, by the user's welcome
It is supported by the body, the pot is a material emitter, stirring rotation and cutting flying knife drive as the power, with the stirring paddle stirring material, so that the material in a short period of time rolling and mixing uniform, and then by cutting flying knife into particles, and then removed from the outlet, change the speed of stirring and cutting flying knife, so as to obtain different sizes of particles equipment
The high-speed mixed granulation machine is constructed with a horizontal cylinder and is constructed reasonably The inflatable sealed drive shaft can be switched into water when cleaned Flow-state granulation, grain-like, approximately spherical, good liquidity 25% fewer adhesives and shorter drying times than conventional processes Each batch dry mix 2 minutes, granulation 1-4 minutes, the efficiency than the traditional process 4-5 times higher Completed in the same closed container, dry mix-wet mix-granulation, process reduction, in line with GMP specifications, the entire operation also has strict safety measures
High-speed mixed granulators are very convenient to use, but the heat loss in use has been relatively large, for this reason we have to take corresponding measures to reduce the related consumption, which can not only improve work efficiency, but also increase the overall economic benefits According to industry insiders, the general reduction of heat loss has to avoid high-speed mixed granulation machine overload and optimize heat transfer two ways, but the more effective method is to strictly control the fuel air ratio, operation close to the fuel air ratio, but also to control fuel consumption Usually the existing control equipment can also be used for maintenance, the main operation is as follows: 1 direct heat recovery products If the exhaust gas leaving the high temperature part can enter a relatively cold feed load, the energy will be transferred to the preheating load, which reduces the energy discharged with the exhaust pipe, which can effectively utilize the waste heat in the exhaust gas
2 Use residual heat recovery to preheat the burning air This is often used in medium- to high-temperature industrial furnaces, where the use of preheated air burners reduces the amount of fuel required to purchase fuel to meet process heat requirements, and preheats combustion air requires a heat exchanger or recycling
3 Waste heat boiler Boiling granulators introduce the use of waste heat boilers to recover some of the heat of waste gas is a need for steam or hot water, waste heat boilers are similar to traditional boilers, with one exception, it is heated by high-speed mixed granulators in the exhaust gas flow rather than their own burners.