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An important part of the development and growth of different parts of the human body is the decomposition of organs and structures in the previous stage
.
The most obvious example is the metamorphosis of insects, but this process also occurs in the development of human gonads and the degeneration of mammary glands after lactation
A study led by the head of the development and morphogenesis of the IRB Barcelona Fruit Fly Laboratory and IBMB-CSIC researchers, Dr.
Jordi Casanova and Dr.
Jérôme Solon, described the disintegration of the trachea during metamorphosis in fruit flies
.
This process is carried out in two stages
.
The first phase involves shortening/constriction of the trachea, which results in compaction of the cell membrane, which triggers the second phase, which is characterized by cell death
"Ultimately, aging is a stage of development, in which structures will be disassembled due to use or wear
.
If we want to understand aging and strive to promote the health of the elderly, it is vital to understand these processes," said Dr.
"An interesting aspect of this process is the complex involvement of physical mechanisms and biological signals, which lead to the disintegration of multicellular organs
.
Together they regulate cell decisions and organ remodeling
Original Search: Control of hormone-driven organ disassembly by ECM remodeling and Yorkie-dependent apoptosis
Current Biology (2021) DOI: 10.
1016/j.
