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How chronic pain occurs

 Last Update: 2022-04-26
 Source: Internet
 Author: User

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therapeutic

central drug system

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Image: Section of the dorsal horn of the mouse spinal cord

An epigenetic factor and an organic anion transporter (OAT1), whose function in the nervous system has so far been unknown, contributes to the development of chronic pain

"Normal, acute physical pain prevents tissue damage and, in the case of injury, heals

Researchers have now identified an epigenetic factor, histone deacetylase 4 (HDAC4), which is a key factor in gene expression in dorsal horn neurons

In collaboration with Prof.

To further test this approach, the researchers administered the OAT1 blocker Probenecid to mice

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