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Image: Combining stopped-flow dynamics measurements with molecular dynamics simulations revealed molecular details of the passage of small polar compounds (water and lactate) through a model cell membrane
Bacteria, fungi, and yeast are very good at excreting useful substances, such as weak acids
Boundary control is very important for cells
synthetic vesicles
This is a problem for the biotech industry, which uses cells as factories to produce large quantities of useful substances, and these working cells are required to survive harsh conditions, such as high concentrations of alcohol or weak acids
So he combined these two questions in a research project
Adjustment
The fatty acid tails of lipids have the greatest effect on membrane properties, while hydrophilic headgroups have little effect on membrane permeability
Therefore, Poolman and his colleagues defined variables that alter the membrane permeability of different classes of compounds
drug design
An increased understanding of the physical processes that affect permeability could help companies understand why certain cells are better suited to specific processes than others
Another application is the design of intracellularly acting drugs
article title
Membrane thickness, lipid phase and sterol type are factors that determine membrane permeability to small solutes
