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Now, researchers have developed a new method of 3D culture to accurately quantify how cancer cells generate forces to spread within tissues
The research, a collaboration between scientists at Aalto University and Stanford University, is published in the journal Nano Letters
Nanospheres measure build-up into more powerful force pulses
Primary tumors can form within breast ducts, where cancer cells are bound by a special membrane called the basement membrane
"Under this mechanism, breast cancer cells use the forces generated by the protrusions to open channels within the membrane material
The new study used 3D cell cultures composed of breast cancer cells and standard basement membrane material
This allowed the researchers to measure force pulses from cancer cells
"This is currently the most accurate way to measure how cellular forces are generated in 3D cultures," Pokki added
Towards more efficient and personalized drug development
Breast cancer is the most common cancer in women worldwide
Developing drugs to treat breast cancer is expensive, slow and often inefficient, as less than 5% of drug candidates selected using 2D cell cultures and animal experiments are effective in human clinical trials
"Our method provides a more accurate calculation of cellular forces as breast cancer cells invade
Luka Sikic, Ester Schulman, Anna Kosklin, Aashrith Saraswathibhatla, Ovijit Chaudhuri, Juho Pokki.
