 Home > Biochemistry News > Biotechnology News > HIV infection: a better understanding of the virus pool in the body

HIV infection: a better understanding of the virus pool in the body

 Last Update: 2022-01-09
 Source: Internet
 Author: User

Tags

thorium nuclear power

famous female scientists

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

CD4+ T cells are an important part of the immune system and play a key role in protecting the body against pathogens
.

Because they have a variety of defense mechanisms against HIV in the resting state, they are rarely infected-but the few infected cells form a latent reservoir of HIV in the body, which currently cannot be reached by antiviral drugs

Quiescent CD4+ T cells are hardly adapted to genetic manipulation, because existing methods usually assume cell division, Keppler explained
.

"Static cells do not divide by definition

In the future, researchers will be able to eliminate individual genes and entire signaling pathways and analyze their functions
.

By knocking out the corresponding genes, they have managed to figure out whether four previously controversial cytokines play a role in HIV infection

On this basis, they sought a second "knock-in" method, that is, inserting additional or slightly modified genes, such as the green fluorescent protein (GFP) gene
.

With the help of this protein, researchers can analyze changes in the activity of target genes under specific conditions, or label specific proteins

Journal Reference :

Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías-Pérez, Madeleine Gapp, Andreas Linder, Niklas A.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

L-Ascorbate-2-Monophosphate Feed Grade

CAS No.: 109620-90-8

Feed Grade

Potassium Sorbate from reliable manufacturer

CAS No.: 590-00-1

Food Grade

Doxycycline Hydrochloride

CAS No.: 10592-13-9

Pharmaceutical Grade

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.