High salt intake can alter the gut bacteria in mice

, published online november 16th,
said high salt intake could alter the gut bacteria in mice. Given the growing recognition of the role of gut microbiomes in disease, these findings highlight the potential of the gut microbiome as a potential therapeutic target against salt-sensitive diseases.
high salt intake is associated with a modern lifestyle that can lead to high blood pressure and cardiovascular disease, and may also drive autoimmunity by inducing inflammatory TH17 cells, which have been associated with high blood pressure.
To determine the effect of high salt intake on gut bacteribus composition, Dominik Müller of the Max del Bruck Molecular Medical Center in Berlin, Germany, and colleagues analyzed excreta samples from mice fed normal and high-salt salt foods. It was found that by the 14th day, there was a significant reduction in a variety of microorganisms in mice fed high-salt foods. They then used 16S CR DNA gene sequencing and calculation methods to identify the most important reduced bacillus groups and found that lactobacillus murinus, a genus Lactobacillus murinus, was most associated with high-salt foods.
further studies have shown that injecting Lactobacillus murinus into mice reduces TH17 cells and prevents salt-induced deterioration of actively induced experimental autoimmune encephaloblastitis (mouse model of encephalitis) and salt-sensitive hypertension. Another small leading study in healthy humans found that increased salt intake reduced the survival of a variety of Lactobacillus bacteria, accompanied by an increase in TH17 cells and an increase in blood pressure, consistent with the findings. Nevertheless, further research is needed in humans. (Source: Zhang Zhang/Compilation, China Science Daily)