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On July 26, 2022, Zhao Yang's research group at Peking University and the Joint Center for Life Sciences published a research result
How to obtain a large number of functional hepatic parenchymal cells is an important and urgent problem
In this study, the researchers found that in the earliest stages of the reported chemically induced pluripotent stem cell reprogramming system, transcription factors that expressed some of the development and function of hepato parenchymal cells, such as Nr2f1, Hnf1b, Hhex, and Onecut1
Figure 1.
Subsequently, studies of the molecular pathways of chemical reprogramming found that the progressive activation of liver-enriched transcription factors such as Foxa1/2/3, Cebpa, Nr1i2, Hnf4a, and Nr1h4 mediated the induction
In summary, the study realized the direct reprogramming of fibroblasts by using the step-by-step activation of liver enrichment factors by using chemical small molecules, and obtained functionally mature hepatic parenchymal-like cells
In addition, the earliest stages of the chemically induced pluripotent stem cell reprogramming system are activated in addition to transcription factors associated with the liver lineage, but also include a series of important transcription factors
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