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| Heavy! New study finds the cause of the new coronavirus destroying the lungs |
Scientists at the Brookhaven National Laboratory of the U.
S.
Department of Energy published the first detailed atomic-level model of the new coronavirus envelope protein (Envelope protein, E protein) in the journal Nature Communications on the 8th.
This protein is related to the maintenance of the lungs.
A human lung cell connexin called PALS1, which is necessary for mucosa, binds
.
The model shows how these two proteins interact, helping to explain how the virus causes extensive lung damage in particularly vulnerable patients with new coronary pneumonia, and escapes the lungs to infect other organs
The envelope protein of the new coronavirus and its spike protein are present on the outer membrane of the virus to help the virus assemble new particles in the infected cell
.
Early research has shown that envelope proteins play a key role in hijacking human proteins to promote virus release and spread
Scientists speculate that the envelope protein breaks the connections of lung cells in a certain way
.
When lung cell connections are destroyed by the new coronavirus, immune cells try to repair the damage and release small proteins called cytokines
.
This immune response may trigger large-scale inflammation, leading to the so-called "cytokine storm" and subsequent acute respiratory distress syndrome, thereby aggravating the condition
This time, the researchers quickly frozen the sample by mixing the envelope protein and PALS1 together, and then used cryo-electron microscopy (cryo-EM) to study the membrane protein and the dynamic protein complex, and found the details of the dynamic interaction between the proteins
.
Using the observed structural features, the researchers created a molecular model
The model has information about the individual amino acids that make up these two proteins, provides structural details and an understanding of the intermolecular forces that allow the envelope protein to “pull PALS1 away from the outer boundary of lung cells deep within the infected cell.
Open"
.
In other words, the envelope protein of the virus “pulls” the PALS1 protein out of their usual job of keeping lung cells tightly connected by binding to the human body's PALS1 protein
Liu Qun (transliteration), a structural biologist at the Brookhaven Lab and the lead author of the study, said: “When the viral protein pulls PALS1 out of the cell connection, it can help the virus spread more easily.
Provide a selective advantage to the virus
.
Any feature that increases the survival, spread, or release of the
Researchers said that finding the cause can help find drugs that specifically prevent the new coronavirus from having this effect, thereby reducing the virus's lethality on the human body
In addition, understanding the dynamics of this protein interaction will also help scientists track how viruses such as the new coronavirus have evolved
Focus on the new crown pneumonia epidemic
