"Heavy taste" therapy finds a scientific basis

as an important means of a variety of pain treatment, seemingly "heavy taste" of zirconiotherapy has been called by medical institutions and patients at home and abroad. However, little is known about the mechanism by which the herring plays analgesia or anesthesia. Scientists have recently found the key to understanding the secret, starting with the forested mountain otters.
Forest Mountain is a genus of shanko, mainly inhabited in the wet mountain grasslands or waters near the body length of about 3 cm, in Indonesia, Myanmar, Vietnam, India and Yunnan, China and other places are distributed. Compared with the otters, the individuals are small, the amount of blood absorbed is small, and they need to be ingentered multiple times. As a result, the researchers determined that yams needed stronger anticoagulants, anti-inflammatory and analgesic active substances to support their efficient and rapid blood-eating, and to try to keep the blood-sucking "wrong head" from being perceived.
Previously, the scientific community had believed that blood-sucking herring indirectly inhibited the pain response of blood-sucking animals by inhibiting neophil activation, hypertrophic cellular trypsin activity, and complement systems, but the latest study suggests that they should have an efficient, direct analgesic or anesthetic active ingredient based on their habits.
Not long ago, led by Lai Wei, a long-time researcher in natural medicine functional proteomics at the Kunming Zoological Research Institute of the Chinese Academy of Sciences, and Professor Sun Zhaoxuan of Guangzhou General Hospital of the Kunming Institute of Plant Research of the Chinese Academy of Sciences, a brand-new family of neurotoxic polypeptides was isolated from the salivary glands of forest mountains and named HSTX. Members of this toxin family contain 23 to 25 amino acid residues, possess two molecular intra-sulfur bonds, and perform neurotoxic activity by blocking some sodium ion channels in animals.
sodium ion channel is the main starting key of electrical signals in all animals, which are the basis for the control of a series of physiological processes such as nerve activity and muscle contraction. In addition, the sodium ion channel is also a direct target of many local anesthetics and a large number of neurotoxins in nature, such as snake venom, scorpion venom, spider toxin, etc. are acting on the sodium ion channel and have adverse consequences. The findings, titled "New Sodium Ion Channel Inhibitors from Yamants," were published in the
Journal.
, in 2005, Europe officially approved zirconiotherapy as a legal treatment, with 350,000 otters used for medical treatment in Germany alone each year. From the treatment effect, the effect of otter therapy is more obvious than that of clinical conventional therapy. Numerous literatures have reported the analgesic effect of zirconiotherapy, and long-term clinical practice has proved that zirconiotherapy has good effect on many kinds of pain. (Source: Science and Technology Daily Zhao Hanbin)