Heavy! "Stem cell and transformation research", "protein machine and life process regulation" and other key special 2017 project declaration guidelines recommended release!

On January 12, 2015, the State Council issued the Program on Deepening the Management Reform of the Central Financial Science and Technology Plan (Special, Fund, etc.), which clearly proposed the integration of multiple plans and special projects to form a national key research and development plan.
of June last year, a number of key research and development programs focused on the 2016 project officially unveiled the "veil."
month after the launch, the national key research and development program is "starting again", and the first 16 key project declaration guidelines for 2017 have now been issued.
Since July 29, the Public Service Platform of the National Science and Technology Management Information System has issued 16 key special 2017 project declaration guidelines, including 5 related to biomedical research, including: 1) "Stem Cell and Conversion Research" key special projects 2) "Protein machine and life process regulation" key special, 3) "nanotechnology" key special, 4) "national quality foundation of common technology research and application" key special, 5) "major scientific instruments and equipment development" key special.
"Stem Cell and TransformationAl Research" Focus Special 2017, "Stem Cell and Conversion Research" pilot project will focus on erythropoietic stem cell establishment and dry maintenance, tissue stem cell access, function and regulation, stem cell targeted differentiation and cell differentiation, stem cell transplantation in vivo function establishment and regulation, stem cell-based tissue and organ function repair, stem cell resource bank, the use of animal models of stem cell preclinical assessment, stem cell clinical research and other aspects to continue to support 27 research projects.
"Protein Machine and Life Process Regulation" Focus Special 2017, "Protein Mechanism and Life Process Regulation" focus will be in important cells and biofilm-related protein machines and other major basic scientific issues research areas, high-resolution cryoscopes, magnetic resonance technology and other major technical methods research areas, as well as cancer, immunological and other disease prevention and control of major applications of basic research tasks, to support 26 research directions.
"Nanotechnology" and other key special "nanotechnology", "national quality foundation of common technology research and application" and "major scientific instruments and equipment development" key special projects only part of the content is related to biomedical, see the end of the project declaration guidelines recommended the full text or anthology.
12, 2015, the State Council issued the Program on Deepening the Management Reform of the Central Financial Science and Technology Plan (Special, Fund, etc.) (hereinafter referred to as the "Programme").
The Program clearly states that the National Key Basic Research and Development Program, the National High-Tech Research and Development Plan, the National Science and Technology Support Plan, the International Science and Technology Cooperation and Exchange Project, the Industrial Technology Research and Development Fund managed by the Development and Reform Commission, the Ministry of Industry and Information Technology, and the special research projects for public welfare industries managed by the relevant departments will be integrated to form a national key research and development plan.
The plan, in accordance with the major needs of national economic and social development and priority areas for scientific and technological development, has resulted in a number of key projects with clear objectives and clear boundaries, from basic frontiers and major common key technologies to application demonstrations for whole-chain innovative design and integrated organization.
November 16, 2015, the Ministry of Science and Technology issued the Notice on the Release of the First Project Declaration Guidelines for 2016 for the Pilot Project of the National Key Research and Development Program, and published the Reporting Guidelines for six pilot projects, including Stem Cell and Conversion Research.
February to May 2016, the Ministry of Science and Technology issued in five batches the 2016 project declaration guidelines for key projects in 36 countries.
after several months of review, from June 22 to 25, the Public Service Platform of the National Science and Technology Management Information System has published a list of 2016 projects of 40 national key research and development programs.
of these selected projects have been approved "central financial funds" of more than 50 million yuan.
, only nine projects of the "Research on Reproductive Health and Major Birth Defect Prevention and Control" were approved for a total of $360 million.
Details: "Stem Cell and Conversion Research" Pilot Special 2017 Project Declaration Guidelines recommend that, in order to raise the level of stem cell research in China and promote the transformation and application of relevant research results, in accordance with the Outline of the National Medium- and Long-Term Science and Technology Development Plan (2006-2020) According to the Program of the State Council on Deepening the Management Reform of the Central Financial Science and Technology Plan (Special, Fund, etc.), the Ministry of Science and Technology, together with experts from the Ministry of Education, the Health and Family Planning Commission, the Chinese Academy of Sciences, the Natural Science Foundation and the Ministry of Health, has prepared a pilot special implementation plan for stem cell and transformational research.
Stem cell and transformation research pilot special in accordance with the transformation-oriented, solid foundation, break through bottlenecks, achieve leading ideas, to enhance the core competitiveness of China's stem cell conversion applications as the goal, to China's multiple neural, blood, cardiovascular, reproductive and other systems and liver, kidney, pancreas and other organs of major diseases treatment for Demand traction, facing the forefront of international stem cell research and development, focusing on the major basic scientific problems and bottleneck key technologies of stem cell and transformational research, striving to achieve original breakthroughs in scientific theory and core technologies in the key areas of advantage, promoting the transformation of stem cell research results into clinical applications, and overall improving the technical level of stem cells and translational medicine in China.
Special implementation program deploys 8 aspects of research tasks: 1. erypotent stem cell establishment and dry maintenance; 2. tissue stem cell access, function and regulation; 3. stem cell targeted differentiation and cell differentiation; 4. In vivo function establishment and regulation after stem cell transplantation; 5. Stem cell-based tissue and organ function regeneration; 6. Stem cell resource bank; 7. Preclinical evaluation of stem cells using animal models; 8. Stem cell clinical research.
2016, stem cell and transformational research pilot projects focused on the above main tasks, supporting a total of 25 research projects (including 10 projects for young scientists).
According to the special implementation plan and the relevant deployment during the 13th Five-Year Plan period, in 2017, the pilot project of stem cell and conversion research will focus on the establishment and dry maintenance of erypotent stem cells, tissue stem cell access, function and regulation, directed differentiation of stem cells and cell differentiation, After stem cell transplantation, in vivo function establishment and regulation, stem cell-based tissue and organ function repair, stem cell resource bank, the use of animal models of stem cell preclinical evaluation, stem cell clinical research and other aspects of the continued deployment of projects, to give priority to support 27 research directions (each direction to support 1-2 projects).
reporting units for important support directions, for solving major scientific problems and breakthrough key technologies for integrated design, organization and declaration of projects, the objectives of each project must cover all assessment indicators.
encourages the organization of projects around a major scientific issue or application objective, from basic research to applied research.
to rely on national laboratories, national key laboratories and other important scientific research al-Qaida projects.
the implementation period of the project is generally five years.
the number of subjects under the general project shall not exceed 4 in principle, and the number of units contained in each project shall be controlled to 4.
to support the young scientists no more than 10 projects, the total cost of the mission does not exceed 60 million yuan.
young scientists project can refer to the important support direction (except for the standard) to organize the project declaration, but is not limited by the research content and assessment indicators.
1. The establishment and dryness of erypotent stem cells 1.1 multipotental maintenance and early differentiation of the embryo layer Research content: combined with embryo linee markers, functional screening and single-cell technology, the study of human erythromychnic stem cell erythromypotent maintenance, differentiation of early cell heterogeneity and genealogy differentiation regulation.
Assessment indicators: identification of more than 5 new erratic marker molecules, discovery of 1-3 new mechanisms for the establishment and maintenance of erraticity, discovery of more than 1 type of differentiation of early heterogeneity establishment and evolution mechanism, discovery of more than 5 kinds of regulation of early embryo formation of new genes and clarify mechanisms.
1.2 Transcription Regulation of Stem Cell Destiny Research: Key Transcription Factors, Cofactors, and DNA Modification Regulate Cell Destiny.
assessment index: combined with stem cells and animal models, three transcription factors, five cofactors and a new cell fate regulation mechanism involving new DNA modification and its combination, and explained the characteristics and common laws of the evolution of at least one genealogical stem cell hierarchy.
1.3 Egenetics Regulation in Cell Programming and Reprogramming Research: Key chromatin structures that affect cell fate in the process of omnicnicnic stem cell self-renewal, differentiation or reprogramming, new nucleic acid modification, non-coded RNA or post-translation modification, etc.
assessment index: Taking human omnicnicnic stem cells as the research object, we found five new oscic genetic regulatory factors in the process of omnicnicnic stem cell stem cell dry maintenance and fate decision-determining, and how to co-regulate cell fate transformation factors;
1.4 Cell Cycle and Pluripotent Maintenance and Differentiation Research: The characteristics of stem cell cycle and the role of cell cycle in pluripotent maintenance, symmetry and asymmetry division, cell differentiation and fate decision.
assessment indicators: the discovery of more than 3 different types of stem cell cycle regulatory factors, the clear 1-3 cell cycles affect stem cell behavior, ernally maintained and genealogical differentiation of the new mechanism, the establishment of a set of regulation of cell cycle to promote stem cell self-renewal and differentiation quality of new technologies.
1.5 Mechanisms and Applications of Ernogenic Withdrawal and Genealogy Differentiation Research Content: In combination with gene editing and markers, study the synergy between errogeneous withdrawal and genealogy decision;
assessment indicators: the establishment of 2 kinds of erypotent stem cells to nerve, blood and other genealogy differentiation molecular model, the clarification of 2 kinds of erythral withdrawal and genealogy decision of the co-regulation mechanism, the establishment of 2 kinds of directional differentiation efficient access to functional cells new methods, new systems and purification strategies.
2. The obtain, function and regulation of stem cell fate in regeneration and regulation Research: the effect of cell property conversion on tissue regeneration in liver or kidney damage.
assessment indicators: the establishment of 1-2 organs, tissue damage research model, the establishment of more than 1-2 new cell tracer technology, the discovery of 1-2 tissue regeneration stem cell proliferation, differentiation, transformation of new molecular mechanisms, found and clarified more than 2 tissue damage induced cell property conversion, cell response and cell property conversion on tissue regeneration.
2.2 Genetic and pregenetic regulation of stem cell aging Research content: molecular basis of stem cell aging, genetic and pre-genetic regulation and intervention strategies.
assessment indicators: reveal 3 different types of stem cell aging molecular mechanism, clarify the genetic and osogenetic regulation of more than 2 kinds of stem cell aging process, through screening and other strategies to find more than 2 kinds of new targets to intervene stem cell aging.
2.3 Tissue Stem Cell Genealogy Hierarchy, Regulation and Preparation Research: Origin, differentiation, and destiny of adult stem cell development such as nerve, heart, interstuming, or blood.
assessment indicators: building a genealogy differentiation map of more than 3 adult tissue stem cells, finding functional markers of more than 3 different developmental potential tissue stem cells, revealing 1-3 stem cells and microenciential interactions to regulate the fate and function of stem cells, and establishing 3-5 new strategies and systems for human tissue stem cell acquisition, dry maintenance and large-scale amplification.
2.4 Characteristics and Evolution of Tissue Stem Cell Mutations Research Content: Combined with animal models and clinical samples to study the mutation characteristics of the substitum of endostrophin stem cells, heterogeneity and tissue stem cell-driven somatic cell mutations, evolution and selection of somatic cell mutations in physiological and pathological conditions.
assessment index: to clarify the mechanism and composition characteristics of more than 3 tissue stem cell mutations, to reveal the effect of more than 3 tissue stem cell pools and proliferation activities on mutation formation, to identify more than 2 tissue stem cell driver cell mutations, to clarify its role in stem cell development or abnormal proliferation, and to reveal the occurrence and evolution of more than 2 tissue stem cell mutations.
2.5 Interaction and regulatory mechanism between micro-environment and stem cells Research content: the interaction of adult tissue micro-environment and stem cells such as heart, intestine, kidney, lung or skin and its effect on stem cell function.
Assessment indicators: to clarify the composition, structure and mechanism of more than 3 kinds of tissue microennity to stem cell dry maintenance and tissue development of adult tissue, to clarify the changes of more than 2 kinds of microencienties under pathological conditions such as injury, aging and malignant transformation, and to reveal the role of more than 2 kinds of microencient and stem cell interaction in disease occurrence and damage repair.
3. Stem cell targeted differentiation and cell differentiation 3.1 erneural stem cell differentiation regulation Research content: combined with non-human primate models, the study of human erythebnic stem cells (embryonic stem cells and induced erythmatic stem cells) differentiation into nerves or myocardial muscles, such as the stage of regulation mechanisms, molecular markers and functional characteristics.
assessment indicators: found more than 3 kinds of human erythnic stem cell system differentiation of the key regulatory factors at all stages, identification of more than 3 kinds of differentiation stages of the hallmark molecules and functional characteristics, the establishment of more than 3 kinds of human erive stem cells exosome cells, functional cells and sub-type functional cells of the efficient differentiation system, the establishment of more than 3 kinds of pregenic cells or functional cells of the quality control standards, verification of more than 2 kinds of human multipotent stem cell differentiation cell transplantation after repair.
3.2 Stem cell-based fertility maintenance and reconstruction Research content: reproductive stem cell fate decision, micro-environmental regulation and artificial matching.
assessment indicators: found more than 3 new factors regulating the self-renewal and differentiation of reproductive stem cells, revealed the characteristics of primate matching and obtained artificial matching, and used stem cells to maintain and rebuild fertility in more than 3 models.
3.3 Endogenetic stem cells or in vivo in-place differentiation promotes regeneration and repair Research content: tissue in-place dedifferentization and differentiation during heart or nerve damage repair, and endogenetic stem cells and cell differentiation are used to promote regeneration and repair.
: establish a research system to label and evaluate endogenetic stem cells;