Heart disease "life-saving drugs" will return to normal supply.

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recentmedia reports, the country has a number of "life-saving drug" sulfuric acid sperm protein injection shortage phenomenon. The essentials for heart surgery cost only a dozen dollars each, but many hospitals have no medicine at their disposal. Some people think that this is in preparation for the price increase.Why is there a shortage of cheap and clinically necessary fish-sulphate protein injections
? Is it really the business in order to prepare for the price increase? 5, the reporter interviewed the relevant departments and experts.
a shortage five years ago, there are only two enterprises producing
it is understood that the fish-thin protein sulfate injection (hereinafter referred to as fish sein) is an anti-heparin drug used for bleeding caused by an overdose of heparin injection. Many heart surgeries require a heart cut, and blood clots as soon as it is drawn, a problem that can be avoided by heparin injections, but can cause bleeding. The role of fish sperm protein is to prevent bleeding, so it is essential in heart surgery. Moreover, there are no alternatives in clinical practice.
reportercomb public reports found that, at present, Guangzhou, Haikou, Kunming, Chengdu, Nanjing and other places of some large hospitals did appear in short supply of fish protein, or inventory only for temporary use.
in fact, the shortage of fish protein occurred five years ago. In 2011, there was a shortage of fish-refined protein in many places across the country, which attracted the attention of government departments. The former Ministry of Health responded by selecting a number of enterprises for targeted production in accordance with the principle of combining government-led and market mechanisms. The Beijing Municipal Drug Administration, by coordinating the city's enterprises to resume production and increase production capacity, finally ensured that the city's drug use is urgently needed.there are many reasons for the shortage of fish protein
. According to a supplier of fish protein raw materials, fish essence protein is an alkaline protein sulfate extracted from mature sperm in deep-sea fish. According to current technology, only from fish sperm, can not be chemically synthesized, so limit production. In addition, marine pollution, reduced fish resources, etc., resulting in a reduction in the supply of raw materials for fish refined protein.
in addition to the supply of raw materials, there are price reasons. Chang Feng, director of the Institute of Pharmaceutical Prices at China Medical University, explained that the price of fish refined protein has been low for a long time, and has not changed for many years, affecting the enthusiasm of production enterprises.
reporters from the General Administration of Food and Drug Administration drug registration system to understand that at present, only two enterprises in the country have the production of fish refined protein qualifications, namely, Shanghai First Biochemical Pharmaceutical Co., Ltd. and Beijing Yuekang Hyatt Pharmaceutical Co., Ltd.
the change sedatiby standard sedituated supply reduction, will return to normal supply in early June
is the shortage really for the sake of price increases?
this, Changfeng told reporters that the shortage of fish refined protein has its particularity. "In 2015, the new version of the Chinese Pharmacopoeia revised the standards of fish essence protein, such as the addition of a cyclophotoinspection check to improve the production requirements of fish essence protein, resulting in the previous production of many fish essence protein from qualified to unqualified, can not be put on the market, fish refined protein supply immediately reduced." He said.
in fact, the relevant authorities have noticed problems brought about by changes in fish protein standards. On March 24, 2016, the State Pharmacopeia Commission issued a notice to revise the 2015 edition of the Chinese Pharmacopeia standard for fish-sulphate sperm protein injection liquid sphertrons, and to remove the photophotometric inspection items from the original standard. On April 29, the General Administration of Food and Drug Administration approved the Pharmacopeia Commission's Request for the Revision of the Fish Protein Standard.
at the same time, the two production enterprises have begun to act. According to reporters, Shanghai's first biochemical has arranged production, is expected to be put on the market at the end of May. Beijing Yuekang has purchased raw materials, but the inspection facilities need to be further complete, is expected to be launched in early June. The first batch of the two companies supplied between 500,000 and 600,000 units to meet clinical needs.
in addition, the National Health and Family Planning Commission Pharmaceutical Management Center on April 29 issued the "2016 clinical lysus, small dosage, market supply shortage of drug fixed-point production enterprises", decided to sulfuric acid semen injection sepsis and other 8 kinds of clinically necessary drugs in short supply for fixed-point production, by the Ministry of Industry and Information Technology, the National Health and Family Planning Commission, the National Development and Reform Commission, the General Administration of Food and Drug Administration jointly negotiated with pharmaceutical production enterprises, through tender selection.
" some places have begun bidding. In Fujian, for example, the winning bid price for fish concentrate protein in 2015 was 22 yuan each. Changfeng said that compared with the past, the price of fish refined protein has indeed increased, which will make the enthusiasm of enterprises also increased, more enterprises to produce fish refined protein, reduce the risk of supply shortage.
shortage drug early warning mechanism must be improved, has been included in this year's key task of medical reform
in recent years, similar to the shortage of cheap drugs such as fish refined protein is not uncommon. According to a sample survey of clinical drug use in more than 40 hospitals nationwide, there are more than 500 kinds of basic drugs added by the state and local levels, of which 342 are in short supply.
, Beijing University International Research Center for Pharmaceutical Management researcher Han Wei pointed out that at present, China's drug shortage early warning mechanism is not perfect, many times to the clinical only found the shortage of drugs. He suggested improving the early warning mechanism and emergency response system for shortage medicines as soon as possible. The first time from the production and circulation of drugs can be monitored or pre-determined to drug shortages, and then through targeted procurement and fixed-point production methods, to increase the market supply. "That's the long-term solution." He said.
relevant authorities have also begun action. According to the 2016 Key Tasks for Deepening the Reform of the Medical and Health System issued by the State Council, this year China will strengthen the guarantee and early warning of the supply of medicines in short supply, select a number of hospitals and primary medical institutions as monitoring points for shortage drugs, and promote the establishment of a normal shortage drug reserve system.
(Chen Haibo)
.