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Cholera is an acute diarrheal disease that has had seven pandemics in the past 200 years
Earlier, the team of Professor Melanie Blokesch of EPFL of the Lausanne Institute of Technology published a groundbreaking paper showing that this bacterium uses a "type VI secretion system"-T6SS molecules steal the DNA of neighboring bacteria-previously described as A tool for competition between bacteria
But it is difficult to study how Vibrio cholerae interacts with gut microbes
Intestinal resistance
Recently, Blokesch's group published a paper in Nature Communications about the way that Vibrio cholerae interacts with bacteria in the human microbiota
Because T6SS is an efficient killing device, bacteria that use T6SS like Vibrio cholerae must also have a way to protect themselves and avoid self-poisoning
Studies have found that some members of the human microbiota can protect themselves from the attack of T6SS without using immune protein pathways
Melanie Blokesch said: "This work has given us some new insights into the behavior of bacterial communities in the gut microbiota, and how the defense against T6SS poisoning can help bacterial populations resist invading pathogens
