Guangdong study successfully inhibits cancer stem cells with RNA gene interference technology

the use of accurate "gene missiles", you can successfully "destroy" stubborn "cancer stem cells" to prevent the recurrence of cancer metastasis! This major scientific breakthrough by Professor Song Erwei,of the SecondHospital affiliated with Sun Yat-sen University, will be published in Cell, the world's leading journal of biologyThis is also the first time that A Cantonese scholars have published a paper in the journalTo this end, not only the Ministry of Science and Technology, the National Natural Science Foundation of China experts have written a promotion, Zhongshan University President Huang Daren yesterday (10th) also rarely wrote praise 37-year-old Professor Song "young and talented."Song is a "sea return" scholar at Harvard University and is known for his scientific research on RNA gene interferenceIn 2003, he successfully applied RNA gene interference technology to the model of protecting explosive hepatitis in mice for the first time, laying the foundation for the application of this technology to theof humandiseases, ranking fourth in the authoritative Science magazine "Top 10 World Technology Breakthroughs 2003"" This time, I'm 'marriage' to the two most popular areas of research, RNA gene interference and cancer stem cells! Song explained that the latest research found why cancer is difficult to cure, the key is in malignanttumorcells have a small number of "cancer stem cells", although the proportion is small, but the capacity of tumor is particularly strong, is considered to be malignanttumortumor, development, metastasis and treatment after recurrence of the root causeThe research, which he led, was successful in interfering with "cancer stem cells" that inhibitbreasted breast cancer using RNA gene interference techniquesBy experimenting in mice, he found that a small molecule RNA called "let-7" was expressed very low in breast "cancer stem cells", so through viral vectors, synthetic proteins were accurately imported into "cancer stem cells" to restore the expression of "let-7" and found that "stem cell characteristics" (these characteristics are the key to cancer stem celltumor , cancer cell metastasis and the production of therapeutic resistance to the body is significantly inhibited, "cancer stem cells" in vitro and the ability to proliferize Therefore, small molecule RNA interference can be an effective treatment for breast cancer stem cells At present, the incidence of breast cancer in China's big cities as high as five per 10,000, and the rate of 3% per year increase, and found that mostly in the middle and late stage, this year's "Lin sister" Chen Xiaoxuxiang lost the soul of the tragedy let the chinese people see the disease terrible Professor Song's achievements will reduce these tragedies He revealed that the current cooperation with the Chinese University of Science and Technology, research and development of "nanocarriers", is expected to declare new drug clinical trials within five years It is reported that at present, the United States has 6 kinds of small molecule RNA technology new drugs into clinical phase 2, 3 trials, but concentrated in hepatitis C, Alzheimer's disease and other fields, has not been involved in tumors Authoritative experts believe that Song Erwei's scientific research results, in the near future to improve the level of diagnosis and treatment of tumors, the benefit of mankind -Character sketch
Chinese Jieqing Song-Wei
thick smile, jumping thinking, and flying gestures.. This constitutes Song Erwei's sketch, a very attractive academic rising star When he was a visiting scholar at Harvard in 2002, he was also a attending physician at Zhongshan II "Sea return" in recent years, his academic growth is like sitting in a "helicopter": Zhongshan University in history from the middle-level to promote to a high-ranking academic, twice on the British "nature" magazine, the full vote was elected China's outstanding youth, the Ministry of Education new century talent , the country's youngest "Changjiang Scholar" This year, he was selected as vice president of Zhongshan II Institute, in charge of scientific research In addition to his busy research and administration, he is also a strong breast surgeon, with 10 operations a week