Grape extract can inhibit hyperglycemia related cognitive dysfunction

A recent study released by researchers from Taipei Medical University found that polyphenols contained in grape extract can inhibit oxidative damage induced by high-fat and high fructose (hfhf) diet and cognitive disorder caused by hyperglycemia in the elderly In this randomized study, eight week old mice were fed a hfhf diet for 66 weeks to induce type II diabetic disorder Then, the mice were divided into four groups: the control group was still fed hfhf diet, the second group was fed hfhf diet with 3% grape powder (LGP group), the third group was fed hfhf diet with 6% grape powder (HGP group), and the fourth group was fed metformin in hfhf diet The results showed that 6% grape powder could significantly reduce the expression of rage and tau protein hyperphosphorylation, regulate the expression of Nrf2 and BDNF, and regulate the phosphorylation of PI3K and ERK in rat brain Studies have long confirmed that increasing the expression of BDNF and Nrf2 is the key to brain function BDNF can play a key role in learning and memory by maintaining the plasticity of synapses, while Nrf2 can prevent brain damage caused by oxidation by regulating the expression of antioxidant protein Long term high fructose and fat diets can cause cognitive disorders related to hyperglycemia, while grape powder supplements can help delay protein damage in the brain associated with neurodegeneration, the researchers said The intake of hfhf with grape powder can inhibit the over phosphorylation of brain and other signal channels that cause brain cognitive damage, so as to improve the learning and cognitive ability of old mice.