Glutamine rehydration metabolism and bone differentiation of interstimcharged stem cells regulated by aging inhibitor ERRalpha

Recently, the degenerative center of the Medical Institute of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences has made new progress in the field of stem cell metabolism regulation, the related paper "Aging inhibits the nuclear subject ERRalpha regulation of glutamine rehydration metabolism and interstitial stem cell bone differentiation" published in the international journal Stem Cell (Stems.2017 Feb; 35 (2): 411-424).
(MSC) is a class of erythmatic stem cells with the potential of self-renewal and multi-way differentiation, with great potential for clinical application.
Stem cell differentiation is affected by internal and external complex factors such as aging, nutrition, hormones, associate researcher Guan Min and research intern Huang Tongling and other newly discovered energy metabolism may be one of the key factors to determine stem cell differentiation, the study found that aging can lead to MSC energy metabolism imbalance, bone differentiation ability weakened, leading to osteoporosis and other metabolic bone Disease, the important nutritional receptor mTOR through the nuclear receptor ERR alpha regulation of glutaminease (GLS), affecting mitochondrial glutamine rehydration metabolism, providing MSC differentiation required nucleic acids, proteins and other biomolecules synthesis of energy needs, improve the aging MSC bone differentiation capacity.
this study reveals the new molecular path mechanism of MSC metabolic regulation and bone differentiation mTOR-ERR alpha-GLS.
research has been supported by the National Natural Science Foundation of China, the Chinese Academy of Sciences Youth Innovation Promotion Fund and the Shenzhen Science and Technology Program.
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