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GlaxoSmithKline/Vir monoclonal antibody sotrovimab is effective against key Omicron mutations

 Last Update: 2022-01-01
 Source: Internet
 Author: User

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On December 2, GlaxoSmithKline (GSK) and Vir Biotech announced an update of a study on the preprinted website bioRxiv: Preclinical data showed that the monoclonal antibody sotrovimab targets the new Omicron SARS-CoV-2 variant ( B.

(For details, see: The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2 )

These data were generated by pseudovirus testing of specific individual mutations found in Omicron

Sotrovimab is a SARS-CoV-2 neutralizing monoclonal antibody that can bind to an epitope shared by SARS-CoV-2 and SARS-CoV-1 (the virus that causes SARS).

Sotrovimab targets a conserved epitope of S protein that is unlikely to mutate over time

Reference source: Preclinical data demonstrate sotrovimab retains activity against key Omicron mutations, new SARS-CoV-2 variant

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