-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Since the advent of the CRISPR gene editing technology known as "gene magic scissors", it has brought many innovations to the development of biomedicine
A few days ago, Professor Youyang Zhao of Northwestern University School of Medicine and the Stanley Manne Children's Research Institute led the research team to report a new delivery technology in the journal Cell Reports
Since the usual method of delivering CRISPR-Cas9 in a viral vector is not suitable for such cells, the new technology allows genome editing to reach vascular endothelial cells for the first time, according to news from the research institute
The nanoparticles, produced from biodegradable materials, targeted the vasculature without specific enrichment in the liver
▲Schematic diagram of the preparation method of PP/PEI nanoparticles for plasmid DNA delivery (Image source: Reference [1])
In the paper, the researchers validated the new delivery technique in a mouse model
▲Schematic diagram of the research: (Image source: Reference [1])
Prof.
Endothelial dysfunction is the root cause of many diseases, including coronary artery disease, stroke, bronchopulmonary dysplasia, and pulmonary hypertension
Note: The original text has been deleted
References:
[1] Xianming Zhang et al.
[2] First time genome editing made possible on cells lining blood vessel walls.
