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Genetic transformation from cancer to degenerative diseases

 Last Update: 2020-12-16
 Source: Internet
 Author: User

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in the study, Christopher Kaleta of the University of Kiel in Germany and colleagues produced a large data set of aging-related gene expression spectrums from four tissues of four species (humans, mice, zebrafish and fish) at different ages. The authors also analyzed publicly available data for patients with aging-related diseases. It was found that the pattern of gene expression during aging d'aeded from degenerative chronic diseases, which was in contrast to what had been observed in cancer. Similar antagonistic relationships have been found at the genomic level, with cancer and degenerative diseases having a large number of risk allethic genes, but these genes have the opposite effect on the prevalence of both diseases. In addition, the authors showed that the main factors affecting the course of aging-related diseases were associated with the immune system and cell division-related processes.
the authors conclude that the study sheds light on a "check and balance" between cancer and desexual chronic diseases, providing an idea for understanding how common the two change in the aging phase. (Source: Science Network Zhang Zhang)

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