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Image: Reversing insecticide resistance with a novel gene drive system: Treating farmland with insecticides leads to the emergence of insecticide-resistant pests and reduces the diversity of beneficial insects
Source: Bill Lab, UC San Diego
Insecticides play a central role in combating the global impact of mosquito-borne malaria and other diseases
But in recent decades, many insects have been genetically adapted to become less sensitive to the effectiveness of pesticides
Biologists at the University of California, San Diego have now developed a method for reversing insecticide resistance using CRISPR/Cas9 technology
Bier, a professor of cell and developmental biology in the UC San Diego Department of Biological Sciences and the paper's senior author, said: "This technique can also be used to increase the proportion of naturally occurring genetic variation in mosquitoes that Mutations make mosquitoes less resistant to transmission or malaria parasites
The researchers used a modified gene drive technique that uses CRISPR/Cas9 to cut the genome at target sites to spread specific genes in mosquitoes
In the new study, the researchers employed this "allele drive" strategy to restore genetic susceptibility to pesticides, just as wild insects did before they developed resistance
Starting with a population consisting of 83% kdr (resistant) alleles and 17% normal alleles (insecticide sensitive), the allele-driven system reversed this ratio to 13% after 10 generations resistant type and 87% wild type
Similar allele-driven systems could be developed in other insects, including mosquitoes
"Through these allele replacement strategies, it should be possible to achieve the same degree of pest control with less pesticide use," Bier said
"One exciting possibility is to use an allelic drive to introduce new versions of VGSC that are more sensitive to pesticides than wild-type VGSC," suggests study co-author Craig Montell (UC Santa Barbara)
The authors of the study are: Bhagyashree Kaduskar (University of California, San Diego and Tata Genetics Institute and Society), Mr.
Magazine
Nature Communications
DOI
10.
method research
Experimental Study
research topic
animal
article title
Reversing insecticide resistance in Drosophila melanogaster with an allelic drive
Article publication date
12-January-2022
COI Statement
Bill has stakes in two companies he co-founded -- Synbal Inc.
