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Genetic risk for asthma stems from changes in airway cells, study finds

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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"This work will help us identify pathways for asthma interventions that stop mucus hypersecretion or type 2 airway inflammation, allergic reactions that exacerbate asthma.

In this study, the team performed the first airway transcriptome association study (TWAS) in childhood and adult-onset asthma

The team then applied these models to genetic data from more than 300,000 participants in the UK Biobank

In particular, the researchers identified genetic changes in a gene that forms mucus structures (MUC5AC) and another gene that directs the production of mucus-secreting cells (FOXA3)

The research was primarily funded by the National Heart, Lung, and Blood Institute (NHLBI)

"This study shows how more gene expression data from participants in genome-wide association studies can shed light on their biological functions

Journal Reference :

Satria P.

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