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Osteoarthritis (OA) is the most common joint disease among older adults and a leading cause of disability and economic burden worldwide
.
About 500 million people worldwide are afflicted with OA, and its prevalence continues to rise with an aging population and the obesity epidemic
The pathogenesis of OA is thought to be a multifactorial process with a strong crosstalk of genetic alterations, environmental triggers, and adverse behavioral traits
.
Substantial evidence suggests that circadian rhythm disturbances modulate immune responses
So the research team used a genetics-based approach to break down whether sleep disturbances are causally related to osteoarthritis (OA) risk
.
We performed univariate and multivariate Mendelian randomization (MR) analyses using summary statistics from publicly published genome-wide association studies to estimate the causal relationship between sleep disturbance and OA risk
.
Figure 1 Source of the article
Inverse variance weighted (IVW) methods were used as the primary MR analysis, while complementary methods included weighted median, weighted mode, MR-Egger regression, and MR polymorphism residuals and outliers (MR-PRESSO) to detect and correct for the presence of polymorphisms
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RESULTS: There were 228 independent instrumental variables (IVs) for insomnia, and 78, 27, and 8 IVs for sleep duration, short sleep duration, and long sleep duration, respectively
.
Univariate MR analysis indicated that genetically determined insomnia or short sleep duration had an adverse causal effect on overall OA (insomnia
.
OR = 1.
Figure 2.
Association of genetic susceptibility to sleep disorders with OA and subtypes
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(A) Insomnia; (B) Short sleep duration
Figure 2.
The findings suggest that there is evidence that insomnia or short sleep duration has a detrimental effect on OA risk
.
Strategies to alleviate sleep disturbances may be one of the cornerstones of OA protection
Second, most of the exposures and outcomes used in this study were binary, so Wald-type estimates may have biased the causal OR50
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Due to the large sample size included in the MR analysis, the investigators believe that the estimated effect will be close to the true
Third, the researchers were unable to infer a possible U- or J-shaped relationship between sleep disturbance and OA
Fourth, since 23andMe's insomnia GWAS summary statistics were not published, we performed multivariate MR to directly assess the causal relationship of insomnia to OA in UKB
Fifth, pain is a frequent concomitant symptom of OA, but it is difficult to separate the association of SNPs with OA from that with chronic pain in isolation
Finally, on the other hand, population limitations may limit the generalizability of the results in other populations
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Taken together, the findings add to the growing body of evidence surrounding the adverse effects of sleep disturbances on OA risk, emphasizing the importance of improving the diagnosis and management of sleep problems to mitigate their potential adverse effects on OA
.
Original article:
Ni J, Zhou W, Cen H, Chen G, Huang J, Yin K, Sui C.
Evidence for causal effects of sleep disturbances on risk for osteoarthritis: a univariable and multivariable Mendelian randomization study.
Osteoarthritis Cartilage.
2021 Dec 7:S1063- 4584(21)00984-5.
