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Genetic research on heart defects and autism discovers new disease-causing genes

 Last Update: 2021-11-11
 Source: Internet
 Author: User

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Image: M-DATA workflow

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Researchers studied genetic data from patients with congenital heart disease or autism and identified nearly 24 genes that cause heart defects

Many diseases that begin early in life seem to be related to mutations in the same gene

In this new study, the researchers developed an algorithm called M-DATA (Multi-trait De novo mutation Association Test with Annotations), which combines the sequencing data of people with related diseases to identify the cause Disease genes

The researchers concluded that M-DATA was more effective in identifying genes that increase personal risk than analysis that focused on a single disease

Zhao added: "Through the joint analysis of new mutations in congenital heart disease (CHD) and autism, we have discovered new genes that may play an important role in explaining the common genetic etiology of CHD and autism

The research leader Xie Yuhan (transliteration) said: “As a biostatistics student, it is very inspiring to find something meaningful to patients and their families

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