Genetic diversity of the two main malaria-transmitting mosquitoes is announced

genetic
, published online in the British journal 20th, revealed the genetic diversity of the two most important mosquitoes that cause malaria transmission in Africa. Through genetic sequencing, scientists have improved their genetic understanding of these species at the molecular level, which is essential to maximize the effectiveness of pesticides and accelerate the development of new vector control strategies.
malaria is a insect-borne infectious disease caused by infection with the malaria parasite through mosquito bites or the importation of blood from people carrying the parasite. According to the World Health Organization, about 3.2 billion people are at risk of malaria each year. Malaria kills 90 per cent of all deaths in sub-Saharan Africa, mostly among children. Malaria morbidity and mortality have fallen significantly through insecticide interventions, but rising insecticide resistance in mosquito populations, coupled with other adaptive changes, may allow these gains to be lost.
This time, Arisdale Mills, a researcher at the Wellcome Trust Sanger Society in the United Kingdom, and colleagues were involved in a project called "The Gambian Mosquito 1000 Genome", which sequenced the genomes of 765 samples of the Gambian Mosquito and Coluzzii, the main transmitters of malaria in Africa.
samples came from 15 locations in eight African countries and cover a range of ecosystems, including rainforests, savannahs and coastal biota. The team found that the genomes of individual mosquitoes carried between 1.7 million and 2.7 million mutated alleomal genes, proving that they belonged to the most genetically diverse nuclear species.
they have also found the latest positive selection signals in several genes known to affect insecticide resistance, such as a mutation in the Vgsc gene called "kdr" that reduces mosquito susceptible to insecticide DDT and pyrethroids. The authors believe that the high genetic diversity of mosquito populations should be taken into account when designing mosquito prevention and control strategies. (Source: Science and Technology Daily Zhang Mengran)