Gene therapy is expected to alleviate cancer and dementia?

Gene therapy refers to the modification of genetic material (DNA or RNA) to achieve the purpose of treatment

Compared with traditional drugs, gene therapy has the advantages of good targeting and more thorough treatment, and it is a promising new treatment method

At present, some gene therapies have been approved, treatment targets include genetic diseases, cancer, etc.

A group of scientists recently discovered the role of gene therapy in the treatment of cancer and dementia

Recently, researchers at the University of Sheffield have discovered a new method of gene therapy, revealing an important regulatory mechanism that helps our genome stay healthy

Cancer and neurodegenerative diseases are currently two fatal diseases affecting human life

Scientists have recently discovered a new method that can not only help humans to prevent these two diseases to a large extent, but also provides enlightenment and new effective methods for the treatment of cancer patients and dementia patients

They published an article titled "USP11 controls R-loops by regulating senataxin proteostasis" in the journal Nature Communications

Scientists have discovered that when cells in our bodies read DNA to build proteins, they often make mistakes

However, by studying how cells repair DNA damage to maintain our health, scientists have discovered the benefits of three proteins working together

These three proteins are called USP11, KEAP1 and SETX.

By understanding how cells avoid making mistakes and thus avoid certain high-risk diseases in humans, scientists can modify the behavior of these proteins and ultimately achieve the goal of promoting human health

This discovery helps scientists develop diagnostic test methods and drugs that target one or more proteins in order to detect and treat certain types of cancer and neurological diseases as early as possible; this new drug is expected to be useful for cancer and dementia patients Provide new treatments

Sherif El-Khamisy, co-founder and deputy director of the Institute of Healthy Living at the University of Sheffield and a professor at the School of Biological Sciences and Institute of Neuroscience at the University of Sheffield, said: "These findings are not only important for our research, but for future clinical trials.

The drugs we develop will help kill cells, which is what we do when treating elderly cancer patients