Gene editing technology can design new antibiotics
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Last Update: 2021-02-08
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Source: Internet
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Author: User
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In a recent study, researchers at the University of Wisconsin-Madison and the University of California, San Francisco, used the gene-editing tool CRISPR to study specific antibiotic-targeted genes for clues about how to improve existing antibiotics or develop new ones.
researchers transferred Mobile-CRISPRi from common laboratory strains to different bacteria, even some less-researched microbes. This easy-to-transfer feature makes the technology an effective way for scientists to study any disease that causes it.
designed and tested Mobile-CRISPRi with Carol Gross, Oren Rosenberg and other colleagues at the University of California, San Francisco and others. The system reduces the production of gene-mediated proteins, allowing researchers to determine how antibiotics inhibit the growth of pathogens.
results were published january 7 in the journal Nature Microbiology. The authors used a defective CRISPR called CRISPRI, which binds to DNA but cannot be cut. This further prevents other proteins from entering and initiating the expression of specific genes.
researchers show that bacteria become more sensitive to low-dose drug stimuli if they reduce the amount of antibiotic-targeted proteins. It could screen thousands of genes for potential antibiotic targets at once, helping scientists understand how antibiotics work and how to improve them. (Bio Valley)
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