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Bemisia tabaci is a major agricultural pest in the world.
Tomato yellow leaf curl virus (TYLCV), a plant disease that is exclusively transmitted by it, causes crop losses of tens of billions of yuan every year, especially for the production of tomato and other vegetables.
constitute a great threat
.
The research team previously found that TYLCV can infect the brain, eyes, antennae and other parts of Bemisia tabaci, and stimulates Caspase-dependent apoptotic neurodegeneration through the immune inflammatory receptor NLR4 and inflammatory factors Spaetzle 1&2 (eLife, 2020)
On February 11, 2022, the team of researchers from the Institute of Zoology, Chinese Academy of Sciences and the Center for Excellence in Biological Interaction, Chinese Academy of Sciences, Ge Feng and Sun Yucheng, published a research titled "PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection" in Nature Communications In this paper, it was found that Phosphatidylethanolamine-binding protein 4 (PEBP4) is a key molecule in regulating the intracellular immune homeostasis of B.
tabaci
.
TYLCV capsid protein CP activates apoptosis and autophagy simultaneously by hijacking PEBP4 on the plasma membrane of B.
The study found that the TYLCV capsid protein CP can non-competitively interact with Raf1 of the PEBP4 and MAPK pathways to form the CP-PEBP4-Raf1 triple complex, inhibit the phosphorylation of Raf1-MEK-ERK, and reversely activate apoptosis (Figure 1).
); on the other hand, CP destroys the binding of PEBP4 and autophagy-related protein ATG8 through competitive binding, which promotes the dissociation, esterification of ATG8 and initiates autophagy (Figure 2), thereby synchronously stimulating the apoptosis of B.
tabaci and autophagy
.
Pharmacological and genetic experiments show that enhancing the intracellular immunity of B.
How is immune homeostasis maintained and regulated (How is immune homeostasis maintained and regulated?) is one of the "125 Frontier Scientific Questions" published by Science
.
This study elucidates for the first time the intracellular immune basis of TYLCV transmission by B.
Dr.
Wang Shifan from the Institute of Zoology, Chinese Academy of Sciences is the first author of the paper, and researchers Ge Feng and Sun Yucheng are the co-corresponding authors of the paper.
Associate researcher Guo Huijuan and Professor Zhu Keyan from Texas A&M University also participated in the research
.
The research was supported by projects such as the Class B Pilot Special Cultivation Project (XDPB16) of the Chinese Academy of Sciences
Article link: align="justify"> Wang S, Guo H, Zhu-Salzman K, Ge F*, Sun Y*.
https://doi.
Figure 1 TYLCV capsid protein interacts with Raf1 by hijacking PEBP4 in B.
Figure 2 TYLCV capsid protein competes with B.
Figure 3 The immune homeostasis of autophagy and apoptosis is the basis for the long-term coexistence of B.
