GBM and SVZ regions are independent factors in patient survival decline

The subvention of the ventricle (SVZ) is a concentrated area of neural stem cellsglioblastoma (GBM) and SVZ region and tumor removal when the open ventricle was associated with tumor soft meninges spreading, recurrence of distant areas, hydrocephalus after surgery, and decreased survival rate of patientshowever, previous studies have not carefully analyzed the clinical significance of the above factors in the development of gliomaAkshitkumar MMistry, a neurosurgery surgeon at Vanderbilt University Medical Center in Nashville,, N.Hthe method seqsthe main indicators of the study were surgical opening of the ventricle and tumor-affected SVZ regionsThe opening of the ventricle can be determined according to the clearly recorded entry into the ventricle or postoperative MRI imaging to show that the ventricle is connected to the tumor cavityIn MRI imaging, the tumor-reinforced part is adjacent to the membrane area of the lateral ventricle ventricle, which is determined to be the tumor-affected SVZ regionThe researchers analyzed the presence of hydrocephalus, soft meninges spread, recurrence of distant tumors, and non-progressive survival (PFS) and total survival rates in postoperative patientsWhen COX regression analysis was performed, factors such as age, preoperative KPS score, tumor resection degree, postoperative chemotherapy, tumor molecular characteristics (including IDH1/2 mutation, MGMT promoter methylation) were adjustedthe results of thestudy found that of the 232 patients, 85 (36.6%) had open ventricles, 114 (49.1%) GBM and SVZ areas, 19 (8.2%) had hydrocephalus after surgery, 78 (33.6%) tumor sepsis and 59 (25.4%) of the distant epidural relapseMulti-factor regression analysis showed that the tumor was tired of SVZ and the ventricle was not open, with the presence of hydrocephalus (HR?4.20; 95% CI, 1.13-15.7; P-0.03), soft meninges (HR-1.93; 95% CI, 1.14-3.28) the ;P s 0.01), PFS (HR s 2.10; 95% CI, 1.53-2.88; P 0.001) and OS (HR s 1.90; 95% CI, 1.35-2.67; P 0.001) are related to the decreaseThe recurrence of the tumor far-apart was not related to either factor, and there was no interaction between the two variablesconclusion
the final author points out that glioblastoma and SVZ region are closely related to hydrocephalus, soft meninges spread and decreased survival rate after surgeryThere is no direct correlation between ventricle opening and the above results, so opening the ventricle is not an obstacle to maximum safe removal of tumors.