Gastroenterology: Study Reveals Pathogenesis

May 15, 2020 News / Biovalley BIOON / --- According to a recent study, resulting in a mutated factor pancreatitis lies within membrane ion channels, characterized in that calcium specific ion permeableThe groundbreaking discovery was made by a research team at Technical University of Munich (TUM) and the other team from Germany, Japan and France's collaborationThis discovery will help develop new therapies for the treatment and prevention of chronic pancreatitispatients with chronic pancreatitis or pancreatic recurrence permanent inflammationThe authors HeikoWitt explains: "In many cases, those who had too much to drink or smoke too much suffering from the disease or certain drugs in patients with high levels of blood lipids or calcium levels also cause another reason for pancreatitis"
(source: Www.pixabay.com)previous studies have focused on the so-called pancreatic acinar cellsThose responsible for producing digestive enzymesMany patients suffering from hereditary pancreatitis showed a molecular mutations digestive enzymes or enzyme inhibition efficacyIn the current study, researchers found that genetic defects severely limit TRPV6 calcium channel function in early onset of chronic pancreatitisProfessor Witt said: "The defect is substantial TRPV6 develop chronic pancreatitis is a serious global risk factors," he added: "Based on this finding, we now consider the ductal cells as part of the concept of the origin of liver cancer." < br /> using a mouse model, the scientists were able to prove that, in most cases, the lack of the corresponding gene, may lead to changes in the occurrence of inflammation and fibrosis of the pancreas, which is typical of chronic inflammationabnormal calcium channel function may be found to promote the development of pancreatitis provides a new approach for therapeutic interventionIn addition, the findings will become part of the standard method of diagnosis of hereditary pancreatitisThese insights paved for a new research study of the causes of pancreatitis road - no longer focused on the acinar cells and digestive enzymes, but focus on channels and ductal cells and calcium metabolism(Biovalley Bioon.com) Information Source: Researchidentifiesadiseasetriggerforpancreatitis Original source: Masamune, A., etal (2020) VariantsThatAffectFunctionofCalciumChannelTRPV6AreAssociatedWithEarly- OnsetChronicPancreatitis Gastroenterology.doi.org/10.1053/j.gastro.2020.01.005