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Gao Lizeng's research group reversed bacterial-induced tumor resistance and enhanced tumor catalysis-chemotherapy combined treatment with nanozymes...

 Last Update: 2022-03-06
 Source: Internet
 Author: User

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Drug tolerance is the biggest obstacle to chemotherapy for cancer patients, and many patients fail chemotherapy
.

Many recent studies have shown that intratumoral bacteria may lead to tumor chemotherapy resistance by metabolizing antitumor drugs

Recently, Gao Lizeng's group from the Institute of Biophysics, Chinese Academy of Sciences reported a novel anti-tumor strategy based on bifunctional nitrogen-doped carbon nanospheres, including: 1) Carbon nanospheres can be used as nano-inhibitors of cytidine deaminase To overcome the gemcitabine resistance induced by bacteria inside the tumor; 2) The carbon nanospheres have peroxidase-mimicking enzyme activity, which can catalyze the generation of OH from H ₂ O ₂ in the tumor microenvironment , thereby combining tumor catalytic therapy with chemotherapy
.

The previous work of the research group found that doping nitrogen in carbon materials can simulate the structure of porphyrin in natural peroxidase, and endow nanomaterials with a variety of enzymatic activities, including peroxidase, catalase, superoxide Dismutase, oxidase ( Nature Communications 2018), and further combined with the properties of iron and nitrogen-doped carbon materials to construct artificial peroxisomes with various types of enzymatic activities ( Advanced Functional Materials 2021)

Figure 1 Nitrogen-doped carbon nanospheres enhance tumor catalysis-chemotherapy combined therapy by exerting the activities of nanozymes and nanoinhibitors

The research was recently published in the international academic journal Nano Today , and Gao Lizeng, a researcher at the Institute of Biophysics, Chinese Academy of Sciences, is the corresponding author of this paper
.

Professor Xi Juqun from Yangzhou University, postgraduate Wang Yanqiu and Dr.

Article link: https:// align="justify">

(Contributed by: Gao Lizeng Research Group)

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