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On May 25 , 2022 , the team of Professor Gao Jianqing and Associate Professor Han Min from the School of Pharmacy, Zhejiang University proposed a new strategy for the prevention and treatment of tumor metastasis by constructing a responsive post-assembly "polypeptide nanoblanket " in viv.
Tumor-associated secretory factor ( TDSF ) is secreted by orthotopic tumors to induce the development of a pre-metastatic microenvironment before circulating tumor cells actually reach and colonize distant organs at potential metastatic ris.
Based on the successful construction of an animal model of the pre-metastatic microenvironment, the research team recorded the dynamic pathological processes of the stromal microenvironment and the immune microenvironment during the development of the pre-metastatic lung microenvironment, including: fibroblast activation , deposition of extracellular matrix components, increased angiogenesis and permeability, and recruitment of bone marrow-derived immunosuppressive cells ( MDSC ) to exert immunosuppressive functio.
Based on the pathological characteristics of the pre-transfer microenvironment, the research team designed and constructed the pre-transfer micro-environment responsive post-assembled polypeptide molecule FR17 , and examined the film blanket formed by the polypeptide molecule after the pre-transfer micro-environment was fixed and assembled by various technical mea.
Polypeptide FR17 self-assembles to form a "polypeptide nanocarpet" after tumor supernatant stimulation, inhibiting the activation of fibroblasts
Mechanistic studies reveal that the "polypeptide nano-blanket" formed by responsive post-assembly inhibits the development and formation of the pro-metastatic matrix microenvironment by inhibiting the activation of fibroblasts during the early formation of the pre-metastatic microenvironment; suppressing matrix remodeling, angiogenesis and infiltrati.
Polypeptide FR17 showed good anti-metastatic effect in melanoma lung metastasis model and recurrence and metastasis model after orthotopic tumor resectio.
The first author of the research paper is Zhou Yi, a doctoral student from the School of Pharmacy, Zhejiang University, and the corresponding authors are Professor Gao Jianqing and Associate Professor Han Min from the School of Pharmacy, Zhejiang Universit.
