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Further without antibiotic treatment: antibodies + enzymes work together to block resistant strains

 Last Update: 2022-09-20
 Source: Internet
 Author: User

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In the 2001 "Amerithrax" attack, anthrax spores were mailed to news agencies and members of Congress, resulting in at least 22 people falling ill and 5 dead

Bacillus anthracis is a gram-positive rod-like bacterium that can cause anthrax infection

This engineered enzyme with a small number of antibodies breaks the envelope of Bacillus anthracis, allowing the immune system to fight back

Anthrax called the Ames strain is particularly toxic because the bacteria can wrap themselves in a protective film of polyd-glutamate

The study also showed that providing mice with engineered CapD could help treat anthrax infection with the Ames strain without the use of antibiotics

To increase the lifespan of the recombinant enzyme in vivo and produce greater impact, the scientists added PEGs and fused

When tested on mouse models, this structure lasted longer than previous versions, although its activity was reduced

References: Engineering an Fc-fusion of a Capsule Degrading Enzyme for Treatment of Anthrax" 14 September 2022, ACS Infectious Diseases.

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