Fudan University has made important progress in the field of alcoholic liver injury

team study by Shen Xiaoyan, a professor at Fudan University's School of Pharmacy, confirmed that the absence of a sub-linking protein 10 (SNX10) fights liver damage and fat degeneration caused by excessive alcohol consumption. This discovery provides new ideas for reducing liver damage caused by excessive alcohol consumption and is expected to be a potential target for the treatment of alcoholic liver disease. The results of the study, published online in the internationally renowned Journal of Hepatology
Long-term heavy drinking can lead to fatty liver and alcoholic hepatitis, which can lead to liver fibrosis and cirrhosis and even liver cancer. Alcoholic liver damage has become a serious threat to public health. In 2012, alcohol consumption caused more than 3 million deaths, or 5.9 per cent of the world's total deaths. Alcohol-induced cirrhosis accounts for about 40% of liver cirrhosis liver transplants in Europe. In Western countries, the incidence and fatality rate of alcoholic liver disease is very high and is regarded as the most important liver disease. In China, with the changing of people's way of life, the incidence of alcoholic liver disease is also increasing year by year. However, the treatment of alcoholic liver disease remained in place 40 years ago and there is still a lack of targeted control drugs.
study found that knocking out SNX10 inhibits the activity of tissue protease A, increases the stability of the cell lysosome LAMP-2A, and activates molecular partner-mediated autophagy. The latter inhibits protease activity, activates Nrf2-HO1 and AMPK signaling paths, and reduces liver oxidative stress and fat degeneration caused by excessive alcohol consumption, thus protecting liver damage in mice caused by alcohol. For the first time, the study found and revealed the important role of SNX10 in alcoholic liver damage, and targeted intervention SNX10 is expected to be a new way to prevent alcoholic liver damage.
, Yu Yan, a doctoral student at Fudan University's School of Pharmacy, is the first author of the paper, and Shen Xiaoyan, a professor at Fudan University's School of Pharmacy, is the author of the paper. (Source: Science Network Huang Xin)