Fu Jingyuan et al. Nature: Human gut microbiome, exposome and heritability

Nature——[49. 962] 8208 Dutch people from 3 generations and 2756 families were included, and their gut microbial composition, function, antibiotic resistance and virulence factors were analyzed; 1253 microbial taxa, 564 metabolic pathways, about 600 species, 9 core species and cornerstone characteristics (28 species, 53 pathways), found that Prevotella copri dominated the microbiome type; analyzed the relationship between 241 host phenotypes and microbiome, revealing the relationship between microbiota and diet 7519 significant associations among exposure group parameters such as childhood living environment, socioeconomic status, etc. ; found that cohabitation was the main factor affecting the flora, and only 6. 6% of the flora such as Akk bacteria were heritable; different diseases had common microbiome characteristics and coexisted with Regardless of disease, unhealthy gut flora reflects both disease and drug use . 【Editor's comment】 The microbiome is closely related to intestinal disorders, metabolic syndrome and various immune diseases, and it is increasingly becoming a consensus . But going back to the beginning of gut research, the question of what constitutes a healthy or unhealthy gut microbiome remains unanswered . Especially for human microbiota studies, large, in-depth, standardized cohort studies and comprehensive analyses based on well-defined phenotypes are still scarce . Nature has just launched a study based on the Dutch Microbiome Project (DMP) led by Fu Jingyuan from the University of Groningen in the Netherlands. It has conducted a comprehensive analysis and overview of the gut microbiome of the Dutch population, and analyzed the effects of heritability and exposure group (Exposome) on bacteria. swarm impact, aiming to facilitate the development of microbiome-targeted therapeutics . This is another major breakthrough in microbiome research after Fu Jingyuan's team and collaborators published on "Long-term Genetic Stability and Individual Specificity of Human Gut Microbiota" in Cell in 2021 (see article) . 【Original information】 Environmental factors shaping the gut microbiome in a Dutch population 2022-04-13, doi: 10. 1038/s41586-022-04567-7   Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Network . Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and text. Readers are only for reference and please Verify the relevant content yourself .   Copyright Notice 1. Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original author . 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicated. Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient evidence. , bio149 will be deleted within 12 hours after confirmation . 3. Users are welcome to submit original articles to 86371366@qq. com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the sender .

　　8208 Dutch people from 3 generations and 2756 families were included, and their gut microbial composition, function, antibiotic resistance and virulence factors were analyzed; 1253 microbial taxa, 564 metabolic pathways, about 600 species, 9 core species and cornerstone characteristics (28 species, 53 pathways), found that Prevotella copri dominated the microbiome type; analyzed the relationship between 241 host phenotypes and microbiome, revealing the relationship between microbiota and diet 7519 significant associations among exposure group parameters such as childhood living environment, socioeconomic status, etc.
; found that cohabitation was the main factor affecting the flora, and only 6.
6% of the flora such as Akk bacteria were heritable; different diseases had common microbiome characteristics and coexisted with Regardless of disease, unhealthy gut flora reflects both disease and drug use
.


【Editor's comment】

　　The microbiome is closely related to intestinal disorders, metabolic syndrome and various immune diseases, and it is increasingly becoming a consensus
.
But going back to the beginning of gut research, the question of what constitutes a healthy or unhealthy gut microbiome remains unanswered
.
Especially for human microbiota studies, large, in-depth, standardized cohort studies and comprehensive analyses based on well-defined phenotypes are still scarce
.
Nature has just launched a study based on the Dutch Microbiome Project (DMP) led by Fu Jingyuan from the University of Groningen in the Netherlands.
It has conducted a comprehensive analysis and overview of the gut microbiome of the Dutch population, and analyzed the effects of heritability and exposure group (Exposome) on bacteria.
swarm impact, aiming to facilitate the development of microbiome-targeted therapeutics
.
This is another major breakthrough in microbiome research after Fu Jingyuan's team and collaborators published on "Long-term Genetic Stability and Individual Specificity of Human Gut Microbiota" in Cell in 2021 (see article)
.


【Original information】

Environmental factors shaping the gut microbiome in a Dutch population

2022-04-13, doi: 10.
1038/s41586-022-04567-7

---

　　8208 Dutch people from 3 generations and 2756 families were included, and their gut microbial composition, function, antibiotic resistance and virulence factors were analyzed; 1253 microbial taxa, 564 metabolic pathways, about 600 species, 9 core species and cornerstone characteristics (28 species, 53 pathways), found that Prevotella copri dominated the microbiome type; analyzed the relationship between 241 host phenotypes and microbiome, revealing the relationship between microbiota and diet 7519 significant associations among exposure group parameters such as childhood living environment, socioeconomic status, etc.
; found that cohabitation was the main factor affecting the flora, and only 6.
6% of the flora such as Akk bacteria were heritable; different diseases had common microbiome characteristics and coexisted with Regardless of disease, unhealthy gut flora reflects both disease and drug use
.


【Editor's comment】

　　The microbiome is closely related to intestinal disorders, metabolic syndrome and various immune diseases, and it is increasingly becoming a consensus
.
But going back to the beginning of gut research, the question of what constitutes a healthy or unhealthy gut microbiome remains unanswered
.
Especially for human microbiota studies, large, in-depth, standardized cohort studies and comprehensive analyses based on well-defined phenotypes are still scarce
.
Nature has just launched a study based on the Dutch Microbiome Project (DMP) led by Fu Jingyuan from the University of Groningen in the Netherlands.
It has conducted a comprehensive analysis and overview of the gut microbiome of the Dutch population, and analyzed the effects of heritability and exposure group (Exposome) on bacteria.
swarm impact, aiming to facilitate the development of microbiome-targeted therapeutics
.
This is another major breakthrough in microbiome research after Fu Jingyuan's team and collaborators published on "Long-term Genetic Stability and Individual Specificity of Human Gut Microbiota" in Cell in 2021 (see article)
.


【Original information】

Environmental factors shaping the gut microbiome in a Dutch population

2022-04-13, doi: 10.
1038/s41586-022-04567-7

---

Nature—[49.
962]
included 8,208 Dutch people from 3 generations and 2,756 families, and analyzed data on gut microbial composition, function, antibiotic resistance, and virulence factors; identified 1,253 microbial taxa, 564 Metabolic pathways, about 600 strains, 9 core strains and cornerstone characteristics (28 strains, 53 pathways), and found that Prevotella copri dominates the microbiome type; 241 host phenotypes and microbiome relationships were analyzed, Revealed 7519 significant associations between the microbiota and exposure group parameters such as diet, childhood living environment, socioeconomic status, etc.
It was found that cohabitation was the main factor affecting the microbiota, and only 6.
6% of the microbiota such as Akk bacteria were heritable; Different diseases have common Microbiome signatures and independent of comorbidities, unhealthy gut microbiota reflects both disease and drug use
.


【Editor's comment】The microbiome is closely related to intestinal disorders, metabolic syndrome and various immune diseases, and it is increasingly becoming a consensus
.
But going back to the beginning of gut research, the question of what constitutes a healthy or unhealthy gut microbiome remains unanswered
.
Especially for human microbiota studies, large, in-depth, standardized cohort studies and comprehensive analyses based on well-defined phenotypes are still scarce
.
Nature has just launched a study based on the Dutch Microbiome Project (DMP) led by Fu Jingyuan from the University of Groningen in the Netherlands.
It has conducted a comprehensive analysis and overview of the gut microbiome of the Dutch population, and analyzed the effects of heritability and exposure group (Exposome) on bacteria.
swarm impact, aiming to facilitate the development of microbiome-targeted therapeutics
.
This is another major breakthrough in microbiome research after Fu Jingyuan's team and collaborators published on "Long-term Genetic Stability and Individual Specificity of Human Gut Microbiota" in Cell in 2021 (see article)
.


【Original information】

Environmental factors shaping the gut microbiome in a Dutch population

2022-04-13, doi: 10.
1038/s41586-022-04567-7

---