Front Oncol: Develops the world's first saliva detection technology for concealed throat cancer

2020 May 17 News /BioValleyBIOON / - Recently, research onFrontiersinOncologyan international journal published report, scientists from the Queensland University of technology and other institutions through research and development of a simple saliva test methods that can detect individual early laryngeal cancer have no symptoms and no signs of cancer, the technology is the world's first non-invasive detection means that HPV-DNA extracted from saliva samples to detect infected persons, and persistence of human papillomavirus (HPV) infection is the main cause of the oropharynx (tonsils and base of the tongue throat area) cancerSource: QueenslandUniversityofTechnologyKaiTang researchers said, a series of saliva tests will be able to give a reminder, to help its previous signs of cancer as early as possible in individuals cancer found; it can help researchers only by way of local surgical excision of 2 mm can tonsilThe incidence of laryngeal cancer induced by high-risk HPV is now rising in developed countries, but unfortunately, once disease progression to advanced stages, the patient will need to be very complicated and more effective methods of treatmentIn the US, HPV snatch give the larynx has exceeded common HPV-induced cancers, such as cervical cancer, but cervical cancer is different, date, and there is no effective against oropharyngeal cancer screening toolResearchthe prevalence of HPV, the researchers included 665 healthy individuals, want to make this detection, the owner must first provide their own saliva samples, and found that when the HPV-16 when the DNA, the researchers will repeat the monitoring, if HPV-16 persist for some time in the body of the patient, then it suggests the presence of the name of the individual potential cancer riskIn this study, individual researchers have reported in the 36 consecutive months of positive status of HPV-16DNA, and when it after 6 months, 12 months and 36 months of testing, individual organism of HPV-16 DNA number will steadily riseThe researchers found that the left amygdala of patients with squamous cell carcinoma of 2 mm, then they tonsillectomy untreated, it can perhaps improve the cure rate in a patient a very simple means of disposing; saliva of patients with postoperative also not again detected the presence of HPV-16DNAresearcher Professor Punyadeera said that this was the first case of asymptomatic cases of laryngeal occult histologically confirmed and identified by screening saliva case, the latter we also need more extensive confirmatory studies are needed to confirm this finding, we must fully assess the presence of the causes and mechanisms of HPV-DNA levels in saliva elevated mode, or because they can be found as a key marker of early cancer patients was as a researcherFinally the researchers said that at present they are very confident of oropharyngeal cancer screening, but they are also an urgent need for large-scale studies to confirm the results of this study, but also need to find sustained against HPV-DNA in saliva suitable evaluation path or route patient presenta (Biovalley Bioon.com) Original Source: KaiDunTang, SarjuVasani, TourajTaheri, etal, AnOccultHPV-DrivenOropharyngealSquamousCellCarcinomaDiscoveredThroughaSalivaTest , > FrontiersinOncology (2020) .doi: 10.3389 / fonc.2020.00408