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Treatment options for advanced biliary tract cancer (BTC, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer) are relatively limited
Treatment options for advanced biliary tract cancer (BTC, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer) are relatively limited
The study retrospectively analyzed patients with advanced BTC who received PD-1 inhibitors combined with chemotherapy (anti-PD-1+C group) or chemotherapy alone (C group) in the Department of Oncology, General Hospital of the Chinese People's Liberation Army
The study retrospectively analyzed patients with advanced BTC who received PD-1 inhibitors combined with chemotherapy (anti-PD-1+C group) or chemotherapy alone (C group) in the Department of Oncology, General Hospital of the Chinese People's Liberation Army
During the study period, 59 patients received chemotherapy alone, and 75 patients received chemotherapy + PD-1 inhibitor treatment
The median PFS of patients in the anti-PD-1+C group was 5.
PFS
The study further evaluated whether the differences in the primary tumor site, liver metastasis, and the number of metastatic organs would affect the PFS of the two groups (group C and anti-PD -1+C)
The highest non-hematological grade 1-2 AE was alopecia (41.
Adverse reactions
In summary, studies have shown that the addition of PD-1 inhibitors to patients with advanced BTC on the basis of first-line chemotherapy can improve the PFS of patients with controllable toxicity
In summary, studies have shown that the addition of PD-1 inhibitors to patients with advanced BTC on the basis of first-line chemotherapy can improve the PFS of patients with controllable toxicity
Original source:
Gou M, Zhang Y, Liu T, Si H, Wang Z, Yan H, Qian N and Dai G (2021) PD-1 Inhibitors Could Improve the Efficacy of Chemotherapy as First-Line Treatment in Biliary Tract Cancers: A Propensity Score Matching Based Analysis.
Gou M, Zhang Y, Liu T, Si H, Wang Z, Yan H, Qian N and Dai G (2021) PD-1 Inhibitors Could Improve the Efficacy of Chemotherapy as First-Line Treatment in Biliary Tract Cancers: A Propensity Score Matching Based Analysis.
Front.
Oncol.
11:648068.
doi: 10.
3389/fonc.
2021.
648068
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