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Background: Angiogenesis is a major factor in the development of inflammation in rheumatoid arthritis (RA), as the formation of pannus provides nutrients and oxygen to infiltrating immune cells and proliferating synovial cells
Angiogenesis is a major factor in the development of inflammation in rheumatoid arthritis (RA), as the formation of pannus provides nutrients and oxygen to infiltrating immune cells and proliferating synovial cells
RESULTS: Serum EMMPRIN/CD147 levels were decreased in RA patients treated with TCZ, and circulating miR-146a-5p and miR150-5p expressions were enhanced, as well as decreased angiogenesis, manifested by a decrease in the number of tubular structures formed by the EaHy926 endothelial cell line
Figure 1 The changes of angiogenic factors in the serum of RA patients before and 4 months after TCZ treatment.
Figure 1 The changes of angiogenic factors in the serum of RA patients before and 4 months after TCZ treatment.
Figure 2 Changes in disease activity score DAS28 were not associated with differences in angiogenic factor concentrations with the exception of EMMPRIN/Tsp-1 ratios
Figure 2 Changes in disease activity score DAS28 were not associated with differences in angiogenic factor concentrations with the exception of EMMPRIN/Tsp-1 ratios
Figure 3 TCZ treatment increases serum expression of miR-146a-5p and miR-150
Figure 3 TCZ treatment increases serum expression of miR-146a-5p and miR-150
Culture promotes angiogenesis
Culture promotes angiogenesis
Our findings suggest that miR-146a-5p is involved in the regulation of EMMPRIN, suggesting that TCZ affects angiogenesis by affecting EMMPRIN and miR-146a-5p
Zisman D, Safieh M, Simanovich E, et al.
Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.
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