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Front Immunol: Targeting FcRN: A New Way to Treat Pemphigus

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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hyperphosphatemia treatment

anti dna antibody

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, Keratinocytes adhere to desmosomes on the skin and mucous membranes, leading to acantholysis

, Free Ig is sorted into lysosomes and degraded

Schematic illustration of the effect of inhibiting FcRN on pemphigus disease activity

Schematic diagram of the effect of inhibiting FcRN on pemphigus disease activity

ALXN1830 reduced the levels of IgG and IgGIC in all patients

Therefore, it may be contraindicated for pregnant women to use the drug

The status of FcRN inhibitors in the existing treatment options for pemphigus

Original source:

Bosch-Amate X, Iranzo P, Ivars M, Targeting the FcRn: A Novel Approach to the Treatment of Pemphigus, Front Immunol 2021;12

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