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Research background: The combination of basic research and clinical research has made rheumatism research advance by leaps and bounds
.
At the diagnostic level, the discovery of RA anti-citrullinated peptide antibodies is another breakthrough
METHODS: The protein morphologies of latent, activated, complex and truncated gelatinase A/MMP-2 and gelatinase B/MMP-9 were detected by zymography to compare their specificity levels, with substrate switching assays Methods The net proteolytic activity was detected, and the truncated protein variants were analyzed by Western blot
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The sensitivity of citrullination detection was enhanced by using a new monoclonal antibody that improved citrulline
RESULTS: All protein forms of MMP-9 and MMP-2 in synovial fluid were identified by zymography, and the expression of MMP-9 and MMP-2 in various arthritic diseases including rheumatoid arthritis (RA) was identified.
level was studied
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Second, we addressed misconceptions about MMP-9 levels and proteolytic activity
Conclusion: Rheumatoid arthritis synovial fluid contains higher levels of MMP-9, including truncated and citrulline-type proteins
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Combining matrix metalloproteinase-9 (MMP-9) as an analyte with its citrullinated PTM may have clinical applications, especially in the field of arthritis
Rheumatoid arthritis synovial fluid contains higher levels of MMP-9, including truncated and citrulline-type proteins
Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids.
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