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Front Immunol: Novel effects of combination therapy in the induction of pyroptosis in lupus nephritis by inhibiting Caspase-1/Gasdermin D

 Last Update: 2022-02-17
 Source: Internet
 Author: User

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Background: Lupus nephritis (LN) is an inflammation of the kidneys caused by the autoimmune disease systemic lupus erythematosus (SLE)

Lupus nephritis (LN) is an inflammation of the kidneys caused by the autoimmune disease systemic lupus erythematosus (SLE)

Objective: The combined treatment of mycophenolate mofetil, tacrolimus and steroid in lupus nephritis (LN) is effective

Methods: The expression and activation of GSDMD in human and mouse LN kidney tissues were detected by immunohistochemical staining and immunoblotting

RESULTS: The expression level and degree of lysis of GSDMD were significantly increased in renal tissue specimens from LN patients and mice

Conclusions: Combination therapy inhibits caspase-1/GSDMD-mediated pyroptosis and delays disease progression in vitro and in vivo

Combination therapy inhibits caspase-1/GSDMD-mediated pyroptosis and delays disease progression in vitro and in vivo

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