Front Immunol: Male COVID19 patients had a higher mortality rate.

September 24, 2020 /--- -- Men die more from COVID-19 than women, according to a new review by Israel's BIDMC Medical Center.
a review published in Frontiers in Immunology, BIDMC researchers-clinicians looked at gender-based physiological differences that may affect the risk and susceptivity of COVID-19, the course and clinical outcomes of the disease, and the response to vaccines.
"The COVID-19 outbreak is now showing significant gender differences, with a significant increase in male mortality compared to women," said co-author Dr. Vaishali R. Moulton, an assistant professor of medicine in the Department of Medicine.
" In addition to differences in behavior and lifestyle factors between men and women, sex chromosome chain genes, sex hormones, and microbiomes control all aspects of the immune response to infection and may be important biological causes of our gender-based differences.
" (Photo: www.pixabay.com) Moulton et al. argue that demographic differences between men and women put each group at different risk.
, for example, men are more likely to smoke, which is a known risk factor for severe COVID-19, and are more likely to suffer from cardiovascular disease and high blood pressure, which is an important potential combination of COVID-19.
women are more likely to work in health care, increasing their potential exposure to the virus.
, however, many animal and human studies have shown that women have a stronger immune response to infection than men, a trait that may be associated with increased sensitivity to inflammatory and autoimmune diseases.
Looking back at literature on gender-based differences in immune system cells, X chromosome chain genetics, sex hormones, ACE-2 ligands, and microbiomes, the scientists concluded that gender is a vital but under-studied and often overlooked variable.
"Vaccine-related research and clinical trials, including ongoing research and clinical trials on COVID-19, must use gender as a key variable in measuring and reporting results," said Moulton, an assistant professor of medicine at Harvard Medical School in Washington, D.C.
understanding these factors will help us better understand COVID-19 and guide the design of effective therapies and vaccine strategies toward gender-based personalized medicine.
Bioon.com Source: COVID-19 mortality rates higher among men than women Source: Nirupa Gadi et al, What's Sex Got to Do With COVID-19? Gender-Based Differences in The Host Immune Response to Coronaviruses, Frontiers in Immunology (2020). DOI: 10.3389/fimmu.2020.02147.