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Front Immunol: cellular and molecular phenotypes of pConsensus Peptide (pCons)-induced lupus CD8+ and CD4+ regulatory T cells

 Last Update: 2022-02-17
 Source: Internet
 Author: User

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which regulatory T cells (T _reg ) play a protective role in many inflammatory and autoimmune diseases including SLE

Regulatory T cells (T _reg ) are protective in many inflammatory and autoimmune diseases, including SLE

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In the present study, we further investigated the molecular and cellular phenotypes of pCon-induced CD4 ⁺ and CD8 ⁺T _reg

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We found that pCons significantly increased the percentage of CD8 ⁺ FoxP3 ⁺ T cells and further increased the mean fluorescence intensity (MFI) of FoxP3, healthy peripheral blood mononuclear cells (pmcs) treated with pCons (10mg/ml, 24-48 hours)

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These data suggest that pCons stimulate cellular, immune, and molecular changes in regulatory T cells that protect against SLE autoimmunity

Cellular and Molecular Phenotypes of pConsensus Peptide (pCons) Induced CD8 and CD4 Regulatory T Cells in Lupus.

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