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From structure to clinical muscarinic M1 receptor agonist may become a new treatment for AD

 Last Update: 2022-01-03
 Source: Internet
 Author: User

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CompilationFan Dongdong

A few days ago, a group of scientists and pharmaceutical collaborators succeeded in discovering a new designed drug that is expected to improve the treatment of Alzheimer's disease in the future

The research was carried out by the University of Glasgow (Glasgow) and the biotechnology company Sosei Heptares Ltd.

For now, there are no drugs on the market that can prevent or delay the progression of Alzheimer's disease

Andrew Tobin, professor of molecular pharmacology at the University of Glasgow and director of the newly established Advanced Research Center, said that after years of gestation, the global collaboration of the University of Glasgow with Sosei Heptares and other company partners has resulted in a highly complex drug design method that activates the brain.

Both parties confirmed that although the M1 receptor is very similar to other types of muscarinic receptors, it is still possible to successfully design selective modulators using the mastered 3D structure of the M1 receptor.

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