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From disaggregating cellular differentiation dynamics to cell types and pluripotency landscapes

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Figure: (A) Gene Regulatory Network (GRN.

In multicellular organisms, cells develop from a single pluripotent/stem cell and differentiate into different cell types during proliferatio.

Since the interactions between different genes are complex and highly nonlinear, the energy landscape theory utilizes non-equilibrium potentials to describe the steady-state distribution of noisy GRN systems and constructs an approximate gradient system that easily describes the differentiation proces.

Published in National Science Review, scientists from the Chinese Academy of Sciences, Peking University, Tokyo University, and Fudan University have proposed a new energy landscape decomposition (ELD) theory that considers cell birth and deat.

This unified theory of the energy landscape of the underlying energy landscape and PBA can effectively characterize the dynamic behavior of cellular systems, and the ELD proposed in this study can help to understand the system of cell proliferation and death, not just pure reaction.

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