FPH: Chinese scientists review article to interpret the pathogenesis, symptoms, diagnosis and current therapy progress of COVID-19

2020 May 17 News /BioValleyBIOON / - COVID-19 is a disease caused by the SARS-Cov-2 coronavirus, which is currently 212 countries have been infected in more than 400 million people, of which there are at least 27.2 million deaths, affecting COVID-19 to bring economic and social shocking, despite the large number of reports about COVID-19 every day, but few outsiders know, COVID-19 caused the patient's death is mainly caused by the excessive activation of the immune system, and immune system function is precisely to help the body resist infectionSource:NIHRecently, an article published in the International Journal ofFrontiersinPublicHealthreview article from China Zunyi Medical institutions and other scientists on the epidemiological characteristics of severe COVID-19, and the spread of disease pathways, symptoms, diagnosisand current therapies are discussed, the researchers stressed that the immune system COVID -19 progression potentially fatal overreaction may lead to play a key rolearticle, the researchers explain how SARS-Cov-2 infection of the respiratory tract and multiply in the cell, while in severe cases reveals how the virus through the "cytokine storm" to cause excessive immune defenses this is a cytokine storm excessive activation of leukocytes, which is released into the blood capable of large number of cytokines, i.epro-inflammatory moleculesProfessor DaishunLiu researchers pointed out that the same situation with SARS and MERS occur after infection, the data show that serious COVID-19 cytokine syndrome occurs in patients, this rapid increase in excess of cytokines will attract immune cells (such as lymph cells and neutrophils, etc.), thereby causing these cell infiltration into the lung tissue and cause lung damagecytokine storm will eventually lead to fever, excessive vascular leakage, in vivo coagulation, extremely low blood pressure, hypoxia, and high blood acidity and the like of occurrence of pleural effusionLeukocytes will be incorrectly guided to attack and infect healthy tissue, causing the lungs, heart and other organ failure, which induced multiple organ failure syndrome (MODS), and this may worsen due to the formation of a transparent film and closed lung function, which species transparent film made of protein and fragments of dead cells, which will be arranged in the lung tissue, so that oxygen absorption body becomes difficult, so COVID-19 because most of the deaths caused by respiratory failure causedaddition, the study, the researchers also explains why the current lack of treatment COVID-19 specific antiviral therapy, and therapeutic purposes COVID-19 must be lower than the symptoms by strengthening the maintenance of organ function to reduce mortality of the patient, such as a blood purification system using the artificial liver or renal replacement therapy in patients with blood filtering body by mechanical meansOf particular importance is a method of addition to or instead of lung function, such as non-invasive mechanical ventilation through the mask, through the vent pipe, or by administering cardiopulmonary bypass pipe within the nasal cavity and the likeresearchers also stressed the importance of the prevention of SARS-Cov-2 secondary infection, SARS-Cov-2 will invade the intestinal tissue and cause inflammation of the intestinal lining tissue in the gut and leakage, and induce opportunistic infections pathogenic microorganisms; researchers advocate to prevent secondary infection of the virus by way of nutritional support, such as the use of probiotics to protect the body, while intake of nutrients and amino acids can also help improve host the body's immune defenses and intestinal functionFinallyresearcher Liu said treatment COVID-19 due to the current dependent on the patient's clinical symptoms of the raw active treatment, and prevention of such a bacteria and fungi a secondary support for organ infection from disease worsened particularly important, especially the heart, kidneys and liver and other organs(Biovalley Bioon.com) Original source:PengXie, WanyuMa, HongboTang, etalSevereCOVID-19:AReviewofRecentProgressWithaLookTowardtheFuture/> FrontiersinPublicHealth, 2020; 8DOI: 10.3389 / fpubh.2020.00189