Four parts of institutional innovation of Shanghai Pharmaceutical Research Institute make researchers become "hundred million yuan households" more quickly

Under the background of leading generic drugs and scarcity of original drugs in China, Shanghai Institute of pharmaceutical research, Chinese Academy of Sciences has recently produced new drug achievements - "artemethine maleate", an original candidate drug for the treatment of systemic lupus erythematosus, which has just received clinical approval; another new anti pulmonary hypertension drug has been reported to the National Drug Review Center for review According to the "first action plan" of the Chinese Academy of Sciences, the reporter walked into the "Pharmaceutical Innovation Research Institute of the Chinese Academy of Sciences" to be built in Shanghai Shanghai Pharmaceutical Institute, as the main body of its construction, is through the pilot reform of "use, disposal and revenue management of scientific and technological achievements" of the central level institutions, using system innovation to stimulate the transformation of achievements, so as to speed up the listing of these high value-added original new drugs, and also make researchers more quickly become "100 million yuan households" 1 First part: paper or achievement Like most domestic scientific research institutes, Shanghai Pharmaceutical Institute has many patents, but the patent conversion rate is not high The proportion of patents that the whole institute really realizes transformation is only a single digit Jiang Hualiang, director of the Institute, said that the low conversion rate is not due to the low patent level, but because under the current title evaluation system, the paper output is far more valuable than the achievement conversion Therefore, the research focus of researchers naturally tends to publish papers on the development of new drugs, while few people pay attention to the transformation of new drugs into the market Under the new mechanism, the new professional title evaluation model of the drug Institute, which is market-oriented, evaluates the transformation results If the new drug obtains the new drug certificate and marketing approval, the new drug research and development team can obtain two senior and four deputy senior titles In this way, the transformation of scientific research achievements and the publication of high-level papers can make researchers obtain "academic promotion" According to statistics, since the pilot project, according to the newly formulated results transformation process, the Institute has transformed four new drug varieties, of which the contract value of two new anti-tumor chemicals is over 100 million yuan The second part: Yang Yushe, a researcher of the Institute of collective medicine or an individual, remembers that more than 10 years ago, the patent transfer fee of Antofloxacin hydrochloride, an antibacterial new drug, was equal to his 50 year salary Of course, the proceeds are not owned by individuals It turned out that if the scientific and technological achievements, as state-owned assets, had formed gains, they would all be turned over to the State Treasury after deducting the part of rewards According to previous regulations, patent awards for drugs such as Antofloxacin hydrochloride are included in the total wages of the Institute of drugs and issued according to the base of the total wages In this way, even if the scientific and technological achievements are successfully transformed, the real profits of the inventors are not much, and personal rewards may even cause the salaries of other colleagues to decline Can we change "negative energy" into "positive energy"? For the current incentive system, Ye Yang, deputy director of the Institute, has a "new account" He told reporters that the achievement income was distributed according to the proportion of "5:2:3": the inventor of the achievement could get half of the income at most; two percent of the income was owned by the team and used for the follow-up research and development; the remaining 30% was used for "back feeding" of drugs and more transformation of scientific and technological achievements Trilogy: slow approval or independent approval may hinder the transformation of scientific and technological achievements by researchers Ye Yang said that in the past, the transformation of scientific and technological achievements worth less than 8 million yuan should be reported to the higher authorities for approval and the Ministry of Finance for filing; while the transformation projects worth more than 8 million yuan must be reported to the higher authorities and the Ministry of Finance for approval at the same time In this way, when the scientific and technological achievements can be transformed into the market, it may be three quarters later Fortunately, Yang Chunhao, a researcher at the Institute of medicine, doesn't have to wait nine months The "national first class new drug" antineoplastic compound developed by his team achieved transformation at the speed of one month All of these benefits from the pilot reform of "use, disposal and revenue management of scientific and technological achievements" and the delegation of the authority of examination and approval to the Research Institute of the central public institutions Therefore, the scientific and technological achievements are handed over to the Institute for unified disposal and independent management On the basis of full investigation, the Institute has designed a strict internal process for the transformation of scientific and technological achievements Through project initiation, evaluation, demonstration, decision-making, publicity and implementation, it is more transparent and fair, which makes their scientific and technological achievements sit on the "through train" for transformation "The earlier a new drug goes on the market, the earlier it can reduce the burden of patients and save their lives", this is the common expectation of researchers Four parts: semi entrepreneurship or mass entrepreneurship, mass innovation - researchers will never be excluded From laboratorial assiduous study, to establish Biotech Corp, it is also their optional path So far this year, the inventors of nearly 10 achievements of the Institute have embarked on the road of entrepreneurship to market their new drug achievements Behind them, we can't do without the institutional support of the drug Institute It is understood that the Institute has given these aspiring researchers two choices: "semi entrepreneurship" and "whole sea" One is to stay for three years without pay Once the number of years has passed, researchers can choose to continue their business or leave the Research Institute The second is the drug Institute's recommended scheme: the researcher only acts as the major shareholder of the start-up enterprise, leaving the company to the professional team for operation, and he will serve in the Institute as usual The market-oriented value of real original drugs is hundreds of millions, billions and billions of dollars Jiang said, "soon, maybe in less than ten years, we will also go out of several billionaires."