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Figure 1
.
Description
of the four DNA methylation epigenetic clocks used in our study.
A new research paper published on the cover of Aging Vol.
14, No.
19 titled "Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites.
"
Aging is a progressive, time-dependent biological process that affects diverse individuals and can sometimes exhibit unusually long lifespan
.
Epigenetic alterations are among the hallmarks of aging, including epigenetic drift in DNA methylation levels and clocks
.
In a new study, researchers Antoine Daunay, Lise M.
Hardy, Yosra Bouyacoub and others used four epigenetic clocks to investigate the DNA methylation age (DNAmage)
of long-lived French individuals in CEPH's aging cohort.
"In the current study, we estimated the age of DNA methylation (DNAmage) using four epigenetic clocks based on small cpg from French centenarians and semi-supercentenarians (CSSC, n=214) and offspring of 90- and 100-year-olds (NCO, n=143)
and the general French population (CG, n=149).
"
DNA methylation analysis of 9 cpgs included in the epigenetic clock showed that they were highly age-correlated (-0.
66>R>0.
54) and that there was epigenetic drift in 4 cpgs, which was only visible
in CSSCs.
DNAmage analysis showed that both CSSC and NCO were younger than their chronological age (CSSC 15-28.
5 years, NCO 4.
4-11.
5 years, CG 4.
2-8.
2 years), and the DNAmage of CSSC was significantly greater than that of CG (p-value< 2.
2e-16).
These differences suggest that epigenetic aging and underlying biological aging slow in individuals with abnormally long-lived lives, and that epigenetic clocks based on small amounts of CPG are sufficient to reveal changes in
the global epigenetic clock.
"This suggests that there has been a slowdown in epigenetic and biological aging in both groups, confirming the results of
three other studies conducted on long-lived individuals in Italy, Australia and Israel.
" In addition, our study demonstrates the possibility
of using an epigenetic clock based on a small number of CpG sites to reveal differences in DNA age and chronological age between individuals with different life expectancies.
