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PLA, a non-natural polyester, is considered one of the most promising "green plastics" due to its excellent properties such as biocompatibility, biodegradability, and high mechanical strength
To date, PLA has mainly been produced by chemical processes consisting of the ring-opening polymerization of lactide (a cyclic dimer of lactic acid) or the direct polymerization of lactic acid
Two-step Synthesis of Polylactic Acid (PLA)
Recently, researcher Tao Fei of Shanghai Jiaotong University is the corresponding author, and Tan Chunlin, a doctoral student of Shanghai Jiaotong University, is the first author of the paper.
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Insufficient light and/or carbon dioxide is widely believed to be responsible for the low growth rate and cell density of cyanobacteria
Compared with low molecular weight chemicals such as ethanol, succinic acid, glycerol and 2,3-butanediol, the in vivo synthesis of the polymer particles was significantly easier to harvest
2.
According to previous studies, along with the analysis, PHA synthase plays a crucial role in affecting the production and molecular weight of polymers
To achieve copolymerization, PHA synthases also need to be engineered to polymerize various substrates
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It is reported that for further development in the future, the team stated that the next step of research is to increase the proportion of dry cell weight of PLA, and it is planned to further increase the proportion of dry cell weight to more than 50%
.
Tao Fei, the corresponding author of the paper, said that on the one hand, the key enzymes were modified by means of protein engineering
.
"We found some problems with the catalytic performance of the enzyme.
At present, its structure has been predicted with AlphaFold2, and in-depth protein engineering research is underway
.
Next, we will focus on how to improve its affinity for precursor substances and PLA.
The speed of chain polymerization to achieve higher catalytic efficiency of the enzyme, so that the overall production capacity of PLA is higher
," he said
.
On the other hand, prepare for industrial production
.
The team hopes to further improve the robustness of the cell chassis, including a series of tolerances, such as high light resistance, pollution resistance, and salt resistance
.
In addition, the team also plans to conduct related research on the self-flocculation of cells before the pilot test of the product
.
The team also has a clear plan for the future development of the technology
.
Tao Fei said, "We plan to carry out pilot testing and optimization of the entire chain through continuous investment of 3-5 years, and improve all indicators to the level of industrialization
.
"
About the corresponding author Tao Fei
About the corresponding author Tao FeiYoung Changjiang Scholar, Young Chief Scientist of National Key R&D Program, Shanghai Youth Science and Technology Star, and Shanghai Pujiang Talent
.
The research field is microbial synthetic biology, which is mainly guided by the sustainable production of bio-based materials, monomer compounds and fine chemicals, based on metabolic science and intelligent design as a means to carry out light, electrical and chemical energy-driven research.
Advanced Biomanufacturing Technology
.
A total of 66 relevant SCI papers (including collaborations) have been published, with more than 1,000 citations
.
Obtained 16 patent authorizations
.
At present, the projects undertaken by him include 1 key research and development plan youth project (chief), 2 general projects of the National Natural Science Foundation of China, 1 youth project of the National Natural Science Foundation of China, 1 sub-project of the key research and development plan of the Ministry of Science and Technology, and 2 sub-projects of the 863 project.
item
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In 2016, he won 1 first prize of the Natural Science Award of the Ministry of Education (ranked third)
.
